Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus
Disclosed is a method for the treatment of diabetes mellitus, especially Type 2 diabetes and conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of a dipeptidyl peptidase IV inhibitor and another antidiabetic agent, to a mammal in need thereof.
1. A method for the treatment of diabetes mellitus and conditions associated with diabetes mellitus in a mammal, consisting essentially of administering an effective amount of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide and 5-[4-[2-(N-methyl-N-(2-pyridyl)aminoethoxy)benzyl]thiazolidine-2,4-dione or a pharmaceutically acceptable salt, ester, solvate, isomer, racemate, or tautomer thereof.
2. A pharmaceutical composition consisting essentially of a dipeptidyl peptidase IV inhibitor isoleucine thiazolidide and 5-[4-[2-(N-methyl-N-(2-pyridyl)aminoethoxy)benzyl]thiazolidine-2,4-dione or a pharmaceutically acceptable salt, ester, solvate, isomer, racemate, or tautomer thereof, and a pharmaceutically acceptable carrier therefor.
3. A process for preparing a pharmaceutical composition consisting essentially of a dipeptidyl peptidase IV inhibitor isoleucine thiazolidide 5-[4-[2-(N-methyl-N-(2-pyridyl)aminoethoxy)benzyl]thiazolidine-2,4-dione or a pharmaceutically acceptable derivative thereof, and a pharmaceutically acceptable carrier, which process comprises admixing the dipeptidyl peptidase IV inhibitor, the 5-[4-[2-(N-methyl-N-(2-pyridyl)aminoethoxy)benzyl]thiazolidine-2,4-dione or a pharmaceutically acceptable salt, ester, solvate, isomer, racemate, or tautomer thereof, and the pharmaceutically acceptable carrier.