Isolated nucleic acid molecules which encode a soluble IL-TIF/IL-22 receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof
The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules encoding the proteins, and uses of the protein, are also described.
1. An isolated nucleic acid molecule which encodes a soluble protein which binds to IL-TIF/IL-22, wherein said nucleic acid molecule encodes a protein, comprising SEQ ID NO: 11.
2. The isolated nucleic acid molecule of claim 1 , comprising the nucleotide sequence of SEQ ID NO: 10.
3. An expression vector comprising the isolated nucleic acid molecule of claim 2 , operably linked to a promoter.
4. A recombinant cell line or cell strain, transformed or transfected with the expression vector of claim 3 .
5. A recombinant cell line or cell strain, transformed or transfected with the isolated nucleic acid molecule of claim 2 .
6. An expression vector comprising the isolated nucleic acid molecule of claim 1 , operably linked to a promoter.
7. A recombinant cell line or cell strain, transformed or transfected with the expression vector of claim 6 .
8. A recombinant cell line or cell strain, transformed or transfected with the isolated nucleic acid molecule of claim 1 .