Phosphonate compounds
View Patent ↗The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
1. An antiviral nucleoside compound, wherein the 5′-hydroxyl group has been substituted for a phosphonate or methyl phosphonate that is covalently linked to an alkylethanediol.
2. The compound of claim 1 , wherein the compound is selected from the group consisting of 2-chloro-deoxyadenosine, 1-β-D-arabinofuranosyl-cytidine (ara-C), fluorouridine, fluorodeoxyuridine (floxuridine), gemcitabine, cladribine, fludarabine, pentostatin (2′-deoxycoformycin), 1-β-D-arabinofuranosyl-guanine (ara-G), 1-β-D-arabinofuranosyl-adenosine (ara-A), and 1-β-D-arabinofuranosyl-uridine (ara-U).
3. A method for the treatment of a viral disease selected from human immunodeficiency virus, influenza, herpes simplex virus, human herpes virus, cytomegalovirus, hepatitis B and C virus, Epstein-Barr virus, varicella zoster virus, orthopox virus, ebola virus and papilloma virus comprising administering an effective amount of a compound of claim 1 optionally in a pharmaceutically acceptable carrier.
4. A method for the treatment of a viral disease selected from human immunodeficiency virus, influenza, herpes simplex virus, human herpes virus, cytomegalovirus, hepatitis B and C virus, Epstein-Barr virus, varicella zoster virus, orthopox virus, ebola virus and papilloma virus comprising administering an effective amount of a compound of claim 2 optionally in a pharmaceutically acceptable carrier.
5. The method of claim 3 , wherein orthopox is selected from variola major and minor, vaccinia, smallpox, cowpox, camelpox and monkeypox.
6. The method of claim 3 , wherein the virus is HIV.
7. The methods of claim 3 , wherein the virus is influenza.
8. The method of claim 3 , wherein the virus is herpes.
9. The method of claim 3 , wherein the virus is cytomegalovirus.
10. The method of claim 3 , wherein the virus is hepatitis B.
11. The method of claim 3 , wherein the virus is hepatitis C.
12. The method of claim 3 , wherein the virus is Epstein-Barr virus.
13. The method of claim 3 , wherein the virus is varicella zoster virus.
14. The method of claim 3 , wherein the virus is papilloma.
15. The method of claim 4 , wherein orthopox is selected from variola major and minor, vaccinia, smallpox, cowpox, camelpox and monkeypox.
16. The method of claim 4 , wherein the virus is HIV.
17. The method of claim 4 , wherein the virus is influenza.
18. The method of claim 4 , wherein the virus is herpes.
19. The method of claim 4 , wherein the virus is cytomegalovirus.
20. The method of claim 4 , wherein the virus is hepatitis B.
21. The method of claim 4 , wherein the virus is hepatitis C.
22. The method of claim 4 , wherein the virus is Epstein-Barr virus.
23. The method of claim 4 , wherein the virus is varicella zoster virus.
24. The method of claim 4 , wherein the virus is papilloma.