Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
1. A compound of structure:
or a pharmaceutically acceptable salt, hydrate, or enantiomer thereof.
2. A compound according to claim 1 wherein said compound has the structure:
or a pharmaceutically acceptable salt or hydrate thereof.
3. A compound according to claim 1 wherein said compound has the structure:
or a pharmaceutically acceptable salt or hydrate thereof.
4. A compound according to claim 1 wherein said compound has the structure:
or a pharmaceutically acceptable salt, hydrate, or enantiomer thereof.
5. A pharmaceutical composition comprising a compound of claim 1 , 2 , 3 , or 4 , and a pharmaceutically acceptable vehicle, excipient, or diluent.
6. A pharmaceutical composition comprising a compound of claim 1 , 2 , 3 , or 4 , and a pharmaceutically acceptable vehicle, excipient, or diluent which is administered in combination with a statin.