Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors

1. A compound of formula I:

wherein R 1 and R 2 are each independently H, or cyclopropyl, wherein the cyclopropyl group may be further substituted with one or more substituents selected from the group consisting of aryl, halogen, —OH, —OR 7 , a heteroalicyclic group, and a trihaloalkyl group;

R 3 and R 4 are H;

R 5 is phenyl, wherein the phenyl group may be further substituted with one or more substituents selected from the group consisting of alkyl, alkoxy, halogen, —OR 7 , —NR 7 R 8 , —NR 7 C(O)R 8 , aryl, —C(O)OR 7 , cycloalkyl, haloalkyl, haloalkoxy, —C(O)R 7 , —NR 7 C(O)OR 8 , —SO 2 R 7 , —NR 7 C(O)NR 9 R 8 , —C(O)NR 7 R 8 and —SO 2 NR 7 R 8 ;

wherein at least one of R 3 , R 4 and R 5 is an aryl;

R 6 is H;

R 7 , R 8 and R 9 are independently H, alkyl, aralkyl, heterocycloalkyl or aryl, wherein the alkyl and aryl may be further substituted with one or more substituents selected from the group consisting of alkyl, aryl, trifluoroalkyl, —OH, alkoxy, amino, —NO 2 and —CN;

alternatively, NR 7 R 8 can form a 5–7 membered heteroalicyclic ring, a 5–6 membered heteroaryl ring, wherein the heteroalicyclic ring may further contain no more than 4 of the heteroatoms (N, O, or S), and the cyclic structure formed about NR 7 R 8 may be substituted with one or more substituents selected from the group consisting of alkyl, haloalkyl, alkoxy, heteroalicylic, aryl, heteroaryl and halo; and

wherein one of R 1 or R 2 is cyclopropyl;

or a pharmaceutically acceptable salt thereof.

2. A compound selected from the group consisting of:

N-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-acetamide,

Cyclopropyl-(3-phenyl-imidazo[1,2-a]pyrazin-8-yl)-amine,

N-[3-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]acetamide,

Cyclopropyl-{3-[3-(2-morpholin-4-yl-ethoxy)-phenyl]-imidazo[1,2-a]pyrazin-8-yl}-amine,

3-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenol,

Cyclopropyl-[3-(3,4-dichloro-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-amine,

3-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-benzoic acid,

Cyclopropyl-{3-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-imidazo[1,2-a]pyrazin-8-yl}-amine,

Cyclopropyl-[3-(4-dimethylamino-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-amine,

Cyclopropyl-[3-(4-phenoxy-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-amine,

1-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-ethanone,

[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-carbamic acid benzyl ester,

[3-(3-Amino-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-cyclopropyl-amine,

4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-benzoic acid,

1-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-3-(3-pyrrolidin-1-yl-propyl)-urea,

1-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-3-(3-morpholin-4-yl-propyl)-urea,

1-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-3-(2-pyrrolidin-1-yl-ethyl)-urea,

1-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-3-(2-morpholin-4-yl-ethyl)-urea,

or or pharmaceutically acceptable salt thereof.

3. A compound selected from the group consisting of:

Cyclopropyl-(3-phenyl-imidazo[1,2-a]pyrazin-8-yl)-amine,

3-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenol,

Cyclopropyl-[3-(4-dimethylamino-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-amine,

1-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-ethanone,

[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-carbamic acid benzyl ester,

[3-(3-Amino-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-cyclopropyl-amine,

[3-(4-Amino-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-cyclopropyl-amine,

(R)-2-Pyrrolidin-1-ylmethyl-pyrrolidine-1-carboxylic acid [4-(8-cyclopropylamino -imidazo[1,2-a]pyrazin-3-yl)-phenyl]-amide,

(S)-2-Pyrrolidin-1-ylmethyl-pyrrolidine-1-carboxylic acid [4-(8-cyclopropylamino -imidazo[1,2-a]pyrazin-3-yl)-phenyl]-amide,

1-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-3-(3-pyrrolidin-1-yl-propyl)-urea,

1-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-3-(3-morpholin-4-yl-propyl)-urea,

1-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-3-(2-pyrrolidin-1-yl-ethyl)-urea and

1-[4-(8-Cyclopropylamino-imidazo[1,2-a]pyrazin-3-yl)-phenyl]-3-(2-morpholin-4-yl-ethyl)-urea,

or a pharmaceutically acceptable salt thereof.

4. A pharmaceutical composition, comprising a compound or a pharmaceutically acceptable salt thereof, according to any one of claims 1 , 2 and 3 , and a pharmaceutically acceptable carrier or excipient.