Antiviral agents
This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals as well as novel intermediates useful in the preparation of the compounds of formula I
1. A compound of formula II:
or salt thereof, wherein:
R 1 is hydrogen, C 1-4 alkyl, halo, hydroxy, mercapto, trifluoromethyl, amino, mono or di(C 1-4 alkyl)amino, cyano, formyl, —CH═NO—C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkoxy, aryloxy, C 1-4 alkylthio, or aryl;
Y is O, S, NH or NMe;
Z is CH;
Alk is C 1-6 alkylene; and
R 11 is OR 10 or SR 10 , where R 10 is C 1-4 alkyl.
2. A compound of formula III:
or salt thereof, wherein:
R 1 is hydrogen, C 1-4 alkyl, halo, hydroxy, mercapto, trifluoromethyl, amino, mono or di(C 1-4 alkyl)amino, cyano, formyl, —CH═NO—C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkoxy, aryloxy, C 1-4 alkylthio, or aryl;
Y is O, S, NH or NMe;
Z is CH;
Alk is C 1-6 alkylene; and
R 11 is OR 10 or SR 10 , where R 10 is C 1-4 alkyl.
3. A compound of formula V:
or salt thereof, wherein:
R 1 is hydrogen, C 1-4 alkyl, halo, hydroxy, mercapto, trifluoromethyl, amino, mono or di(C 1-4 alkyl)amino, cyano, formyl, —CH═NO—C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkoxy, aryloxy, C 1-4 alkylthio, or aryl;
Y is O, S, NH or NMe;
Z is CH;
Alk is C 1-6 alkylene; and
R 11 is OR 10 or SR 10 , where R 10 is C 1-4 alkyl.
4. A compound of formula VI:
or salt thereof, wherein:
R 1 is hydrogen, C 1-4 alkyl, halo, hydroxy, mercapto, trifluoromethyl, amino, mono or di(C 1-4 alkyl)amino, cyano, formyl, —CH═NO—C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkoxy, aryloxy, C 1-4 alkylthio, or aryl;
Y is O, S, NH or NMe;
Z is CH;
Alk is C 1-6 alkylene; and
R 11 is OR 10 or SR 10 , where R 10 is C 1-4 alkyl.
5. The compound of claim 2 having the structure:
or salt thereof.
6. The compound of claim 2 having the structure:
or salt thereof.
7. The compound of claim 2 having the structure:
or salt thereof.
8. The compound of claim 2 having the structure:
or salt thereof.
9. The compound of claim 2 having the structure:
or salt thereof.
10. The compound of claim 2 having the structure:
or salt thereof.
11. The compound of claim 2 having the structure:
or salt thereof.
12. The compound of claim 2 having the structure:
or salt thereof.
13. The compound of claim 2 having the structure:
or salt thereof.
14. The compound of claim 2 having the structure:
or salt thereof.
15. The compound of claim 2 having the structure:
or salt thereof.
16. The compound of claim 2 having the structure:
or salt thereof.
17. The compound of claim 2 having the structure:
or salt thereof.
18. The compound of claim 2 having the structure:
or salt thereof.
19. The compound of claim 2 having the structure:
or salt thereof.
20. The compound of claim 2 having the structure:
or salt thereof.
21. The compound of claim 1 having the structure:
or salt thereof.
22. The compound of claim 1 having the structure:
or salt thereof.
23. The compound of claim 1 having the structure:
or salt thereof.
24. The compound of claim 1 having the structure:
or salt thereof.
25. The compound of claim 1 having the structure:
or salt thereof.
26. The compound of claim 2 having the structure:
or salt thereof.