Process for the production of triiodotrimesic acid
A new process for the production of triiodotrimesic acid that is used as an intermediate product for the synthesis of x-ray contrast media is described.
1. A process for preparing triiodotrimesic acid comprising reacting triiodomesitylene in an oxidation process with potassium or sodium permanganate in a mixture that consists of acetic acid anhydride, acetic acid and sulfuric acid at a temperature of 10 to 120° C. for 12 to 36 hours, and then isolating the obtained 1,3,5-triiodo-2,4-diacetoxymethylene-6-methylbenzene which is then treated with a base for 1.5 to 34 hours at a temperature of 60 to 100° C., then the reaction solution is neutralized and then it is treated with an aqueous potassium or sodium permanganate solution at a temperature of 60 to 100° C. for 1 to 24 hours in an oxidation process.
2. A process according to claim 1 , wherein the reaction that forms 1,3,5—triiodo—2,4—diacetoxymethylene—6—methylbenzene is performed at 40 to 80° C.
3. A process according to claim 1 , wherein the reaction that forms 1,3,5—triiodo—2,4—diacetoxymethylene—6—methylbenzene is performed for 15 to 25 hours.
4. A process according to claim 1 , wherein the basic treatment of the intermediate product is performed at 80 to 100° C.
5. A process according to claim 1 , wherein the basic treatment of 1 , 3 , 5 —triiodo—2,4—diacetoxymethylene—6—methylbenzene is performed for 3 to 12 hours.
6. A process according to claim 1 , wherein the oxidation of 1 , 3 , 5 —triiodo—2,4—diacetoxymethylene—6—methylbenzene is performed at 80 to 100° C.
7. A process according to claim 1 , wherein the oxidation of 1 , 3 , 5 —triiodo—2,4—diacetoxymethylene—6—methylbenzene is performed for 2 to 4 hours.
8. 1,3,5-Triiodo-2,4-diacetoxymethylene-6-methylbenzene.