IP Library › Granted Patent US 7,186,421
Granted Patent B2
US 7,186,421 · App. 10/952,674 · Granted Mar 6, 2007

Mineral additives for improved processing of compositions containing vitamin E and saw palmetto

Assignee: ProEthic Pharmaceuticals, Inc.
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Quick Facts
Patent No.
US 7,186,421
App. No.
10/952,674
Granted
Mar 6, 2007
Kind
B2
Abstract

Mineral additives for preparing tablet compositions that comprise Vitamin E and optionally saw palmetto. The compositions are preferably formulated with a zinc compound and a selenium compound.

Claims (19)

1. A method of making a tablet comprising d-gamma, d-beta, and d-delta tocopherols (hereafter “tocopherols”) comprising:

a) admixing said tocopherols with zinc and optionally selenium and optionally saw palmetto in a zinc:tocopherol weight ratio of greater than or equal to about 0.44 and an optional a selenium:tocopherol weight ratio of greater than or equal to about 0.0059 to form an admixture, and

b) compressing or molding said admixture into a tablet,

wherein, when present, said saw palmetto is present in a saw palmetto:tocopherol weight ratio of about 18.8.

2. The method of claim 1 wherein said zinc:tocopherol weight ratio is about 0.44, and said selenium:tocopherol weight ratio is about 0.0059.

3. The method of claim 1 wherein said tocopherols are intimately mixed with said selenium in said tablet.

4. The method of claim 1 wherein said tocopherols are intimately mixed with said zinc in said tablet.

5. The method of claim 1 wherein said saw palmetto is intimately mixed with said selenium in said tablet.

6. The method of claim 1 wherein said saw palmetto is intimately mixed with said zinc in said tablet.

7. The method of claim 1 wherein said admixture comprises said saw palmetto.

8. The method of claim 1 wherein said zinc is present as zinc gluconate, zinc tartrate, or zinc citrate.

9. The method of claim 1 wherein said zinc is present as zinc gluconate, and said zinc gluconate comprises 12 wt. % zinc.

10. The method of claim 1 , wherein the selenium is present as an amino acid or protein chelate, and said amino acid or protein chelate comprises 0.2 wt. % selenium.

11. The method of claim 1 , further comprising admixing dicalcium phosphate in said admixture.

12. The method of claim 1 , further comprising admixing magnesium stearate in said admixture.

13. The method of claim 1 , wherein said tablet is compressed into a tablet within about 24 hours of forming said admixture.

14. The method of claim 1 wherein said tablet is an extended release tablet.

15. The method of claim 1 wherein said tablet comprises about 25 mg. of d-gamma tocopherol, about 9 mg. of mixed tocopherols including both d-beta tocopherol and d-delta tocopherol, about 200 mcg. of selenium, and about 15 mg. of zinc.

16. The method of claim 1 wherein said tablet comprises about 320 mg. of saw palmetto, about 12.5 mg. of d-gamma tocopherol, about 4.5 mg. of mixed tocopherols including both d-beta tocopherol and d-delta tocopherol, about 100 mcg of selenium, and about 7.5 mg. of zinc.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 2, 2012
From: KOWA PHARMACEUTICALS AMERICA, INC.
To: POLY PHARMACEUTICALS, INC.
Reel/Frame 027801/0292 →
CHANGE OF NAME Recorded Jan 22, 2009
From: PROETHIC PHARMACEUTICALS, INC.
To: KOWA PHARAMCEUTICALS AMERICA, INC.
Reel/Frame 022137/0158 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 29, 2004
From: HARVEY, BRYCE M.; MADER, V. STAN
To: PROETHIC LABORATORIES LLC
Reel/Frame 015855/0533 →
Continuity (1)
Related Publication 20060068038A1 · Mar 30, 2006