Synthesis of UDP-glucose:
View Patent ↗Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
1. A compound represented by the following structural formula:
or a physiologically acceptable salt thereof.
2. A compound represented by the following structural formula:
or a physiologically acceptable salt thereof.
3. The compound of claim 1 , wherein the compound has an enantiomeric excess of at least 10%.
4. The compound of claim 1 , wherein the compound has an enantiomeric excess of at least 25%.
5. The compound of claim 1 , wherein the compound has an enantiomeric excess of at least 50%.
6. The compound of claim 1 , wherein the compound has an enantiomeric excess of at least 75%.
7. The compound of claim 1 , wherein the compound has an enantiomeric excess of at least 90%.
8. The compound of claim 1 , wherein the compound has an enantiomeric excess of at least 95%.
9. The compound of claim 1 , wherein the compound has an enantiomeric excess of at least 99%.
10. The compound of claim 2 , wherein the compound has an enantiomeric excess of at least 10%.
11. The compound of claim 2 , wherein the compound has an enantiomeric excess of at least 25%.
12. The compound of claim 2 , wherein the compound has an enantiomeric excess of at least 50%.
13. The compound of claim 2 , wherein the compound has an enantiomeric excess of at least 75%.
14. The compound of claim 2 , wherein the compound has an enantiomeric excess of at least 90%.
15. The compound of claim 2 , wherein the compound has an enantiomeric excess of at least 95%.
16. The compound of claim 2 , wherein the compound has an enantiomeric excess of at least 99%.