IP Library › Granted Patent US 7,226,948
Granted Patent B2
US 7,226,948 · App. 10/150,461 · Granted Jun 5, 2007

Treatment of neurodegenerative conditions with nimesulide

Assignee: University of Mount Sinai School of Medicine of the City of New York
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Quick Facts
Patent No.
US 7,226,948
App. No.
10/150,461
Granted
Jun 5, 2007
Kind
B2
Abstract

The present invention relates to the use of nimesulide and structurally related compounds in the prevention and/or treatment of neurodegenerative conditions. It is based, at least in part, on the discovery that nimesulide exhibits a neuroprotective effect against β-amyloid induced cell death. Without being bound to any particular theory, it appears that nimesulide inhibits a non-inflammatory mechanism of neurodegeneration.

Claims (3)

1. A method of providing a neuroprotective effect against β-amyloid toxicity comprising administering, to a population of neurons, an effective amount of nimesulide.

2. The method of claim 1 , wherein the amount of nimesulide administered decreases neuronal cell death by at least 20 percent.

3. The method of claim 1 , wherein the neurons are exposed to a concentration of nimesulide of at least 1 picomolar.

Continuity (4)
Division 0930842400
Continuation In Part 0883140200 · Apr 1, 1997
Provisional Application 6003333200 · Nov 21, 1996
Related Publication 20060059576A1 · Mar 16, 2006