Methods and compositions for treating ocular disorders
The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
1. A pharmaceutical kit comprising the combination of:
(a) oncomodulin;
(b) an axogenic factor; and
(c) a cAMP modulator.
2. The kit of claim 1 , wherein the axogenic factor is mannose, a mannose derivative or inosine.
3. The kit of claim 1 , wherein the cAMP modulator is non-hydrolyzable cAMP analogues, forskolin, adenylate cyclase activators, macrophage-derived factors that stimulate cAMP, macrophage activators, calcium ionophores, phosphodiesterase inhibitors, specific phosphodiesterase IV inhibitors, beta2-adrenoreceptor inhibitors or vasoactive intestinal peptide.