Combinations for the treatment of immunoinflammatory disorders

1. A method for treating a patient who has an immunoinflammatory disorder selected from rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, or multiple sclerosis, said method comprising administering to said patient:

(a) a corticosteroid; and

(b) dipyridamole, wherein said dipyridamole and said corticosteroid are administered simultaneously or within one hour of each other, in amounts and for a duration sufficient to treat said patient, and wherein said dipyridamole is administered orally or intravenously.

2. The method of claim 1 , wherein said corticosteroid is algestone, 6-alpha-fluoroprednisolone, 6-alpha-methylprednisolone, 6-alpha-methylprednisolone 21-acetate, 6-alpha-methylprednisolone 21-hemisuccinate sodium salt, 6-alpha,9-alpha-difluoroprednisolone 21-acetate 17-butyrate, ameinafal, beclomethasone, beclomethasone dipropionate, beclomethasone dipropionate monohydrate, 6-beta-hydroxycortisol, betamethasone, betamethasone-17-valerate, budesonide, clobetasol, clobetasol propionate, clobetasone, clocortolone, clocortolone pivalate, cortisone, cortisone acetate, cortodoxone, deflazacort, 21-deoxycortisol, deprodone, descinolone, desonide, desoximethasone, dexamethasone, dexamethasone-21-acetate, dichiorisone, diflorasone, diflorasone diacetate, diflucortolone, doxibetasol, fludrocortisone, flumethasone, flumethasone pivalate, flumoxonide, flunisolide, fluocinonide, fluocinolone acetonide, 9-fluorocortisone, fluorohydroxyandrostenedione, fluorometholone, fluorometholone acetate, fluoxymesterone, flupredidene, fluprednisolone, flurandrenolide, formocortal, halcinonide, halometasone, halopredone, hyrcanoside, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone cypionate, hydrocortisone sodium phosphate, hydrocortisone sodium succinate, hydrocortisone probutate, hydrocortisone valerate, 6-hydroxydexamethasone, isoflupredone, isoflupredone acetate, isoprednidene, meclorisone, methyiprednisolone, methyiprednisolone acetate, methyiprednisolone sodium succinate, paramethasone, paramethasone acetate, prednisolone, prednisolone acetate, prednisolone metasulphobenzoate, prednisolone sodium phosphate, prednisolone tebutate, prednisolone-21-hemisuccinate free acid, prednisolone-21-acetate, prednisolone-21(beta-D-glucuronide), prednisone, prednylidene, procinonide, tralonide, triamcinolone, triamcinolone acetonide, triamcinolone acetonide 21-palmitate, triamcinolone diacetate, triamcinolone hexacetonide, or wortmannin.

3. The method of claim 2 , wherein said corticosteroid is prednisone or prednisolone.

4. The method of claim 1 , wherein said dipyridamole and said corticosteroid are administered simultaneously.

5. The method of claim 4 , wherein said dipyridamole and said corticosteroid are administered in the same pharmaceutical formulation.

6. The method of claim 1 , wherein said immunoinflammatory disorder is rheumatoid arthritis, psoriasis, ulcerative colitis, or Crohn's disease.

7. The method of claim 6 , wherein said immunoinflammatory disorder is rheumatoid arthritis.

8. The method of claim 6 , wherein said immunoinflammatory disorder is psoriasis.

9. The method of claim 1 , wherein said dipyridamole is administered in an amount of 5 to 600 mg/day, and said corticosteroid is administered in an amount of 0.1-1500 mg/day.

10. The method of claim 9 , wherein said dipyridamole is administered in an amount of 50 to 400 mg/day, and said corticosteroid is administered in an amount of 0.5-30 mg/day.

11. The method of claim 10 , wherein said corticosteroid is administered in an amount of 0.5-10 mg/day.

12. A method for treating a patient who has an immunoinflammatory disorder selected from rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, or multiple sclerosis, said method comprising orally or intravenously administering to said patient a composition comprising dipyridamole and a corticosteroid in an amount and for a duration sufficient to treat said patient.

13. The method of claim 12 , wherein said corticosteroid is algestone, 6-alpha-fluoroprednisolone, 6-alpha-methylprednisolone, 6-alpha-methylprednisolone 21-acetate, 6-alpha-methylprednisolone 21-hemisuccinate sodium salt, 6-alpha,9-alpha-difluoroprednisolone 21-acetate 17-butyrate, amcinafal, beclomethasone, beclomethasone dipropionate, beclomethasone dipropionate monohydrate, 6-beta-hydroxycortisol, betamethasone, betamethasone-17-valerate, budesonide, clobetasol, clobetasol propionate, clobetasone, clocortolone, clocortolone pivalate, cortisone, cortisone acetate, cortodoxone, deflazacort, 21-deoxycortisol, deprodone, descinolone, desonide, desoximethasone, dexamethasone, dexamethasone-21-acetate, dichlorisone, diflorasone, diflorasone diacetate, diflucortolone, doxibetasol, fludrocortisone, flumethasone, flumethasone pivalate, flumoxonide, flunisolide, fluocinonide, fluocinolone acetonide, 9-fluorocortisone, fluorohydroxyandrostenedione, fluorometholone, fluorometholone acetate, fluoxymesterone, flupredidene, fluprednisolone, flurandrenolide, formocortal, halcinonide, halometasone, halopredone, hyrcanoside, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone cypionate, hydrocortisone sodium phosphate, hydrocortisone sodium succinate, hydrocortisone probutate, hydrocortisone valerate, 6-hydroxydexamethasone, isoflupredone, isoflupredone acetate, isoprednidene, meclorisone, methyiprednisolone, methyiprednisolone acetate, methyiprednisolone sodium succinate, paramethasone, paramethasone acetate, prednisolone, prednisolone acetate, prednisolone metasulphobenzoate, prednisolone sodium phosphate, prednisolone tebutate, prednisolone-21-hemisuccinate free acid, prednisolone-21-acetate, prednisolone-21(beta-D-glucuronide), prednisone, prednylidene, procinonide, tralonide, triamcinolone, triamcinolone acetonide, triamcinolone acetonide 21-palmitate, triamcinolone diacetate, triamcinolone hexacetonide, or wortmannin.

14. The method of claim 13 , wherein said corticosteroid is prednisone or prednisolone.

15. The method of claim 14 , wherein said composition comprises 0.5 to 10 mg of prednisone or prednisolone.

16. The method of claim 12 , wherein said immunoinflammatory disorder is rheumatoid arthritis, psoriasis, ulcerative colitis, or Crohn's disease.

17. The method of claim 16 , wherein said composition is administered intravenously.

18. The method of claim 17 , wherein said corticosteroid is prednisone or prednisolone.

19. The method of claim 16 , wherein said composition is administered orally.

20. The method of claim 16 , wherein said corticosteroid is prednisone or prednisolone.

21. The method of claim 19 , wherein said corticosteroid is prednisone or prednisolone.

22. The method of claim 12 , wherein said composition is administered intravenously.

23. The method of claim 12 , wherein said composition is administered orally.

24. The method of claim 12 , wherein said composition comprises 5 to 600 mg of dipyridamole.

25. The method of claim 24 , wherein said composition comprises 50 to 400 mg of dipyridamole.

26. A method for treating a patient who has rheumatoid arthritis, said method comprising orally administering to said patient a composition comprising dipyridamole and a corticosteroid in an amount and for a duration sufficient to treat said patient.

27. The method of claim 26 , wherein said composition consists of active ingredients and excipients, wherein said active ingredients consist of a corticosteroid and dipyridamole.

28. The method of claim 26 , wherein said composition comprises 5 to 600 mg of dipyridamole.

29. The method of claim 28 , wherein said composition comprises 50 to 400 mg of dipyridamole.

30. The method of claim 26 , wherein said corticosteroid is prednisone or prednisolone.

31. The method of claim 30 , wherein said composition comprises 0.5 to 10 mg of prednisone or prednisolone.

32. A method for treating a patient who has psoriasis, said method comprising orally administering to said patient a composition comprising dipyridamole and a corticosteroid in an amount and for a duration sufficient to treat said patient.

33. The method of claim 32 , wherein said composition consists of active ingredients and excipients, wherein said active ingredients consist of a corticosteroid and dipyridamole.

34. The method of claim 32 , wherein said composition comprises 5 to 600 mg of dipyridamole.

35. The method of claim 34 , wherein said composition comprises 50 to 400 mg of dipyridamole.

36. The method of claim 32 , wherein said corticosteroid is prednisone or prednisolone.

37. The method of claim 36 , wherein said composition comprises 0.5 to 10 mg of prednisone or prednisolone.

38. A method for treating a patient who has ulcerative colitis, said method comprising orally administering to said patient a composition comprising dipyridamole and a corticosteroid in an amount and for a duration sufficient to treat said patient.

39. The method of claim 38 , wherein said composition consists of active ingredients and excipients, wherein said active ingredients consist of a corticosteroid and dipyridamole.

40. The method of claim 38 , wherein said composition comprises 5 to 600 mg of dipyridamole.

41. The method of claim 40 , wherein said composition comprises 50 to 400 mg of dipyridamole.

42. The method of claim 38 , wherein said corticosteroid is prednisone or prednisolone.

43. The method of claim 42 , wherein said composition comprises 0.5 to 10 mg of prednisone or prednisolone.

44. A method for treating a patient who has Crohn's disease, said method comprising orally administering to said patient a composition comprising dipyridamole and a corticosteroid in an amount and for a duration sufficient to treat said patient.

45. The method of claim 44 , wherein said composition consists of active ingredients and excipients, wherein said active ingredients consist of a corticosteroid and dipyridamole.

46. The method of claim 44 , wherein said composition comprises 5 to 600 mg of dipyridamole.

47. The method of claim 46 , wherein said composition comprises 50 to 400 mg of dipyridamole.

48. The method of claim 44 , wherein said corticosteroid is prednisone or prednisolone.

49. The method of claim 48 , wherein said composition comprises 0.5 to 10 mg of prednisone or prednisolone.

50. A method for treating a patient who has an immunoinflammatory disorder selected from rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, or multiple sclerosis, said method comprising orally or intravenously administering to said patient a composition consisting of active ingredients and excipients, wherein said active ingredients consist of a corticosteroid and dipyridamole, in an amount and for a duration sufficient to treat said patient.

51. The method of claim 50 , wherein said composition comprises 5 to 600 mg of dipyridamole.

52. The method of claim 51 , wherein said composition comprises 50 to 400 mg of dipyridamole.

53. The method of claim 50 , wherein said corticosteroid is prednisone or prednisolone.

54. The method of claim 53 , wherein said composition comprises 0.5 to 10 mg of prednisone or prednisolone.