Methods and compositions for inhibition of metastasis
This invention generally relates to methods of producing an antibody phage population having affinity for a tumor cell target expressing a metastatic phenotype. The invention further relates to antibody compositions that specifically bind to a cell surface receptor on the metastatic cell.
1. An isolated antibody which specifically binds to an activated αvβ3 integrin receptor which is differentially produced on a cell in a metastatic state compared to a non-metastatic cell, said antibody comprising SEQ ID NO: 2.
2. The antibody of claim 1 , wherein said metastatic cell targets to a tissue selected from breast, brain, lung, liver, or bone.
3. A pharmaceutical composition comprising said antibody of claim 1 .
4. The antibody of claim 1 , wherein the antibody is a ligand mimetic.
5. The antibody of claim 1 consisting of SEQ ID NO: 2.
6. A method for treating cancer in a mammal comprising administering to the mammal an isolated antibody which specifically binds to an activated αvβ3 integrin receptor which is differentially produced on a cell in a metastatic state as compared to a non-metastatic cell, said anitbody comprising SEQ ID NO: 2.
7. The method of claim 6 , wherein the cancer is breast cancer metastasis in said mammal.
8. The method of claim 6 , said antibody consisting of SEQ ID NO: 2.