Pyrazolo[1,5-a] pyridines and medicines containing the same
Compounds represented by the general formula: [wherein R 1 represents methoxy, ethyl, methylthio, etc., R 2 , R 3 and R 4 each represent hydrogen, a halogen, etc., R 5 and R 6 each represent —X 5 —X 6 —X 7 (wherein X 5 represents a single bond or —CO—, X 6 represents a single bond, —NR 3a , etc. and X 7 and R 3a each represent hydrogen, C 1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.
1. A compound represented by the general formula, a salt of the compound or a thereof,
wherein R 7a represents a hydrogen, nitro, —NO or —NHR 7d wherein R 7d represents a hydrogen, t-butoxycarbonyl or benzyloxycarbonyl;
R 7c represents methylene, oxygen or sulfur; and
R 7b represents a halogen, the formula:
wherein R 8a and R 8b each independently represents a hydrogen or C 1-6 alkyl, or R 8a and R 8b optionally bond together to form 1,2-ethylene, 1,3-propylene or 2,3-dimethylbutan-2,3-diyl, the formula:
wherein R 8c , R 8d and R 8e each independently represent C 1-6 alkyl or the formula:
wherein R 40 and R 41 each independently represents methoxy, ethoxy, ethyl, dimethylamino, methyl or halogen, R 42 represents hydrogen, methoxy, methyl or halogen, and Z 1 and Z 2 each independently represent methine or nitrogen.
2. A compound represented by the general formula, a salt thereof or a thereof:
wherein R 5 and R 6 each independently represents the formula —X 5 —X 6 —X 7 , wherein X 5 represents a single bond or —CO—; X 6 represents a single bond, —NR 3a —, oxygen, sulfur, sulfinyl, sulfonyl, C 1-10 alkylene, C 2-10 alkenylene or C 2-10 alkynylene; and X 7 and R 3a each independently represents a hydrogen, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-8 cycloalkyl, C 5-8 cycloalkenyl, C 6-14 aryl, a 5- to 14-membered heteroaryl group, a 4- to 14-membered heterocyclic group, a 9- to 11-membered benzene fused ring group, an 8- to 11-membered heteroaryl fused ring group or a bicyclic 7- to 12-membered hydrocarbon ring group;
R 5 and R 6 optionally bond together to form a 5- to 10-membered ring optionally containing 1 to 4 hetero atoms in the ring and optionally containing carbonyl in the ring;
R 7c represents methylene, oxygen or sulfur; and
R 7e represents halogen, the formula:
wherein R 8a and R 8b each independently represents hydrogen or C 1-6 alkyl, or R 8a and R 8b optionally bond together to form 1,2-ethylene, 1,3-propylene or 2,3-dimethylbutan-2,3-diyl, or the formula:
wherein R 8c , R 8d and R 8e each independently represents C 1-6 alkyl.