Bioerodible conducting materials
The present invention specifically contemplates a polymer, preferably an electrically conductive polymer, derived from substituted pyrrolyl moieties.
1. A method for controlling cell function, proliferation, or differentiation, comprising contacting cells with bioerodible polymer composition comprising a plurality of subunits having a structure of Formula I:
wherein, as valence and stability permit, and independently for each subunit,
X is selected from O and S;
R 1 is selected from H, lower alkyl, hydroxyl, amino, thiol, alkoxy, alkylamino, alkylthio, carbonyl, nitro, cyano, halogen, acyloxy, and acylamino;
R is selected from H and substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, aralkyl, or heteroaralkyl; and
m represents an integer from 0 to 10.
2. The method of claim 1 , wherein: X is O; R is selected from H and lower alkyl; and m is an integer from 1 to 6.
3. A method for controlling cell function, proliferation, or differentiation, comprising contacting cells with a bioerodible polymer comprising a polymer represented by Formula II:
wherein, as valence and stability permit, and independently for each subunit,
X is selected from O and S;
R 1 is selected from H, lower alkyl, hydroxyl, amino, thiol, alkoxy, alkylamino, alkylthio, carbonyl, nitro, cyano, halogen, acyloxy, and acylamino;
R is selected from H and substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, aralkyl, or heteroaralkyl;
m represents an integer from 0 to 10; and
n represents an integer greater than 5.
4. The method of claim 3 , wherein n is an integer from 20 to 10,000.
5. The method of claim 4 , wherein: X is O; and R is selected from H and lower alkyl; m is an integer from 1 to 6.
6. A method for controlling cell function, proliferation, or differentiation, comprising contacting cells with a bioerodible polymer comprising a plurality of subunits having a structure of Formula III:
wherein, as valence and stability permit, and independently for each subunit,
X is selected from O and S;
Z is a substituent that is charged under physiological conditions or is hydrolyzable to such a substituent under physiological conditions;
L is a substituted or unsubstituted alkyl moiety;
R 1 is selected from H, lower alkyl, hydroxyl, amino, thiol, alkoxy, alkylamino, alkylthio, carbonyl, nitro, cyano, halogen, acyloxy, and acylamino;
R is selected from H and substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, aralkyl, or heteroaralkyl; and
m is an integer from 0 to 10.
7. The method of claim 6 , wherein: X represents O; Z represents C(═O)XR, P(═O)(OR) 2 , SO 3 R, + NR 3 , NR 2 , or a guanidine or guanidinium substituent; L is a branched or unbranched lower alkyl moiety; R is selected from H and lower alkyl; and m represents an integer from 1 to 6.
8. A method for controlling cell function, proliferation, or differentiation, comprising contacting cells with bioerodible polymer comprising a region having a structure of the formula:
wherein, as valence and stability permit, and independently for each subunit,
R is selected from H and substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, aralkyl, or heteroaralkyl;
m is an integer from 0 to 10; and
n is an integer greater than 5.
9. The method of any one of claims 1 , 3 , 6 or 8 , wherein the polymer supports the attachment and proliferation of cells.
10. The method of any one of claims 1 , 3 , 6 or 8 , wherein the polymer is electrically conductive.
11. The method of claim 1 , wherein the polymer has a ratio of the R-protected pyrrole to pyrrole moieties containing ionizable groups so as to have a predetermined bioerosion rate.
12. The method of claim 1 , wherein the polymer includes, separately or interspersed with subunits, up to 50% of other heterologous subunits.
13. A method of any one of claims 1 , 3 , 6 , or 8 , wherein the polymer or polymer composition is a film.
14. An implantable medical device method of any one of claims 1 , 3 , 6 , or 8 , wherein the polymer or polymer composition is a pellet.
15. A method of any one of claims 1 , 3 , 6 , or 8 . wherein the cells are cultured on an implantable medical device or structure having a coating comprising the bioerodible polymer.
16. A method of claim 9 , further comprising at least one attachment molecule.