Bone targeting peptides
The present invention relates to compositions comprising unique bone targeting peptides and the use of compositions comprising such peptides to induce bone repair and treat bone related diseases.
1. A purified peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, SEQ ID NO: 25, SEQ ID NO: 26, and SEQ ID NO: 28.
2. The peptide of claim 1 wherein the amino sequence is selected from the group consisting of SEQ ID NO: 22, SEQ ID NO: 24, SEQ ID NO: 25 and SEQ ID NO: 27.
3. The peptide of claim 1 wherein the amino acid is SEQ ID) NO: 22 or SEQ ID NO: 27.
4. A purified peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:15, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 28, further comprising a bioactive compound linked to said peptide further comprising a bioactive compound linked to said peptide.
5. The peptide of claim 4 wherein the bioactive compound is covalently bound to said peptide.
6. The peptide of claim 5 wherein the bioactive agent is selected from the group consisting of chemotherapeutics, nucleic acid sequences.
7. A composition comprising the peptide of claim 1 and a biocompatible material.
8. The composition of claim 7 wherein the biocompatible material comprises a pharmaceutically acceptable carrier.
9. The composition of claim 7 wherein the biocompatible material is a polymer matrix and said peptide and the matrix is coated onto an implantable prosthesis.
10. The composition of claim 7 wherein the biocompatible material comprises a delivery vehicle.
11. The composition of claim 10 wherein the delivery vehicle is a biodegradable polymer.
12. A method for enhancing bone repair, said method comprising the step of contacting a site in need of repair tissue with a composition comprising the peptide of claim 1 .
13. The method of claim 12 wherein the composition is in an injectable form and the step of contacting the site comprises administering the composition locally by injection.
14. The method of claim 12 wherein the step of contacting the site comprises surgically implanting the composition.
15. The peptide of claim 1 wherein the amino acid sequence is SEQ ID NO: 19 or SEQ ID NO: 25.
16. The peptide of claim 15 wherein the amino acid sequence is SEQ ID NO: 19.
17. A composition comprising the peptide of claim 1 and a biocompatible material.
18. The composition of claim 17 wherein the biocompatible material comprises a pharmaceutically acceptable carrier.
19. The composition of claim 17 wherein the biocompatible material is a polymer matrix and said peptide in and the matrix is coated onto an implantable prosthesis.
20. The composition of claim 17 wherein the biocompatible material comprises a delivery vehicle.
21. The composition of claim 20 wherein the delivery vehicle is a biodegradable polymer.
22. The composition of claim 17 , wherein the amino acid sequence is SEQ ID NO: 19 or SEQ ID NO: 25.
23. The composition of claim 22 , wherein the amino acid sequence is SEQ ID NO: 19.
24. The composition of claim 23 wherein the biocompatible material comprises a pharmaceutically acceptable carrier.
25. The composition of claim 23 wherein the biocompatible material is a polymer matrix and said protein and the matrix is coated onto an implantable prosthesis.
26. The composition of claim 23 wherein the biocompatible material comprises a delivery vehicle.
27. The composition of claim 26 wherein the delivery vehicle is a biodegradable polymer.