IP Library › Granted Patent US 7,325,927
Granted Patent B2
US 7,325,927 · App. 11/329,430 · Granted Feb 5, 2008

Method of filtering data for the objective classification of eyes

Assignee: The University of Houston
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Quick Facts
Patent No.
US 7,325,927
App. No.
11/329,430
Granted
Feb 5, 2008
Kind
B2
Abstract

A method for classifying a patient's eye includes the steps of: obtaining normal and abnormal wavefront aberration data from normal and abnormal eyes; fitting the normal and abnormal eye wavefront aberration data with a basis function to decompose the normal and abnormal eye wavefront aberration data into normal and abnormal eye mathematical components; examining the normal and abnormal eye mathematical components to develop mathematical optical filters capable of discriminating between normal and abnormal eyes, using statistical methods to define a probability distribution; obtaining wavefront aberration data from the patient's eye; fitting the patient's wavefront aberration data with a basis function to decompose the patient's wavefront aberration data into the patient's set of mathematical components; examining the patient's set of mathematical components using the mathematical optical filters to generate a patient filter value; and classifying the patient's eye by comparing the patient filter value with the probability distribution.

Claims (21)

1. A method for classifying a patient's eye, comprising the steps of:

a. obtaining normal eye wavefront aberration data from a representative sample of normal eyes;

b. obtaining abnormal eye wavefront aberration data from a representative sample of a first class of abnormal eyes;

c. fitting the normal and abnormal eye wavefront aberration data with a basis function to decompose the normal and abnormal eye wavefront aberration data into normal and abnormal eye mathematical components;

d. examining the normal and abnormal eye mathematical components to develop mathematical optical filters capable of discriminating between normal and abnormal eyes, using statistical methods to define a probability distribution;

e. obtaining wavefront aberration data from the patient's eye;

f. fitting the patient's wavefront aberration data with a basis function to decompose the patient's wavefront aberration data into the patient's set of mathematical components;

g. examining the patient's set of mathematical components using the mathematical optical filters to generate a patient filter value; and

h. classifying the patient's eye by comparing the patient filter value with the probability distribution.

2. The method of claim 1 , wherein the step of examining is done using receiver operating characteristic analysis in the statistical methods.

3. The method of claim 1 , wherein the steps of obtaining wavefront aberration data are selected from the group of methods consisting of using Shack-Hartmann wavefront sensing, ray-tracing, corneal topography, and any method capable of producing wavefront aberration data.

4. The method of claim 1 , wherein the basis function is selected from a group consisting of a Zernike expansion, Taylor series, Fourier series, and any basis function useful in development of optical filters.

5. The method of claim 1 , wherein the wavefront aberration data are obtained for only one ocular component of the eye.

6. The method of claim 1 , wherein the abnormal eyes comprise eyes having abnormalities comprising Keratoconus, Cataract, Lenticonus, Microspherophakia, Keratoglobus, Pellucid Marginal Degeneration, Terrien's Marginal Degeneration, Pterygium, and refractive error.

7. The method of claim 1 , wherein the first class of abnormal eyes are eyes that are using an optical appliance.

8. The method of claim 7 , wherein the optical appliance is taken from the group consisting of contact lenses and intra-ocular lenses.

9. The method of claim 1 , wherein the first class of abnormal eyes are eyes that have had a change in optical properties resulting from the use of an optical appliance.

10. The method of claim 1 , wherein the first class of abnormal eyes are eyes that have had a change in optical properties resulting from surgery.

11. The method of claim 1 , wherein the normal eyes are a second class of abnormal eyes.

12. The method of claim 3 , wherein the corneal topography is performed using a method selected from the group consisting of slit scanning corneal topography, stereographic corneal topography, and any instrument capable of reporting topographic data.

13. The method of claim 1 , wherein the wavefront aberration data are obtained for several ocular components of the eye.

Assignments (2)
CORRECTIVE ASSIGNMENT TO CORRECT THE SERIAL NUMBER 11239430 PREVIOUSLY RECORDED ON REEL 017479 FRAME 0592. Recorded May 25, 2006
From: APPLEGATE, RAYMOND A.; PESUDOVS, KONRAD; MARSACK, JASON
To: HOUSTON, UNIVERSITY OF, THE
Reel/Frame 017704/0055 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 17, 2006
From: APPLEGATE, RAYMOND A.; MARSACK, JASON; PESUDOVS, KONRAD
To: UNIVERSITY OF HOUSTON
Reel/Frame 017479/0592 →
Continuity (2)
Provisional Application 6064290300 · Jan 11, 2005
Related Publication 20060187413A1 · Aug 24, 2006