Peptides and related compounds having thrombopoietic activity
The present invention relates generally to novel peptides and related compounds that have thrombopoietic activity. The compounds of the invention may be used to increase production of platelets or platelet precursors (e.g. megakaryocytes) in a mammal.
1. A compound that binds to an mpl receptor comprising a sequence which is selected from the group consisting of SEQ ID NO 2 to SEQ ID NO 30, inclusive
SEQ ID
PEPTIDE SEQUENCE
NO:
GAREGPTLRQWLEWVRVG
2
RDLDGPTLRQWLPLPSVQ
3
ALRDGPTLKQWLEYRRQA
4
ARQEGPTLKEWLFWVRMG
5
EALLGPTLREWLAWRRAQ
6
MARDGPTLREWLRTYRMM
7
WMPEGPTLKQWLFHGRGQ
8
HIREGPTLRQWLVALRMV
9
QLGHGPTLRQWLSWYRGM
10
ELRQGPTLHEWLQHLASK
11
VGIEGPTLRQWLAQRLNP
12
WSRDGPTLREWLAWRAVG
13
AVPQGPTLKQWLLWRRCA
14
RIREGPTLKEWLAQRROF
15
RFAEGPTLREWLEQRKLV
16
DRFQGPTLREWLAAIRSV
17
AGREGPTLREWLNMRVWQ
18
ALQEGPTLRQWLGWGQWG
19
YCDEGPTLKQWLVCLGLQ
20
WCKEGPTLREWLRWGFLC
21
CSSGGPTLREWLQCRRMQ
22
CSWGGPTLKQWLQCVRAK
23
CQLGGPTLREWLACRLGA
24
CWEGGPTLKEWLQCLVER
25
CRGGGPTLHQWLSCFRWQ
26
CRDGGPTLRQWLACLQQK
27
ELRSGPTLKEWLVWRLAQ
28
GCRSGPTLREWLACREVQ
29
TCEQGPTLRQWLLCRQGR
30.
2. The compound according to claim 1 which is cyclic.
3. The compound according to claim 1 wherein at least one of the amino acid residues has a D configuration.
4. The compound according to claim 1 wherein all of the amino acid residues have a D configuration.
5. A dimer or multimer of the compounds according to claim 1 .