Cucurbit [n] uril compounds and analogs, and methods of making and using the same
Cucurbit[n]uril compounds each containing phthalhydrazide units in a macrocycle wall thereof, which compound is selected from the group consisting of CB[5], CB[6], CB[7] and CB[8] compounds, the compounds having an internal cavity which may be used to contain a guest compound.
1. A cucurbituril compound comprising phthalhydrazide units in a macrocycle wall thereof, which compound is selected from the group consisting of CB[5], CB[6], CB[7] and CB[8] compounds.
2. The cucurbituril compound of claim 1 , which is soluble in water or a polar organic solvent.
3. The cucurbituril compound of claim 2 , wherein the polar organic solvent is selected from the group consisting of CHCl 3 /MeOH, CH 3 CN, DMSO, acetone, CH 2 Cl 2 and DMF.
4. The cucurbituril compound of claim 1 , having a broad absorption in CH 3 CN of λ max =342 nm.
5. The cucurbituril compound of claim 1 , comprising at least two binding sites in an internal cavity thereof for complex formation.
6. The cucurbituril compound of claim 1 , which is purifiable by silica gel column chromatography.
7. The cucurbituril compound of claim 1 , which is a CB [5] compound having phthalhydrazide units in a macrocycle wall thereof.
8. The cucurbituril compound of claim 1 , which is a CB [6] compound having phthalhydrazide units in a macrocycle wall thereof.
9. The cucurbituril compound of claim 1 , which is a CB [7] compound having phthalhydrazide units in a macrocycle wall thereof.
10. The cucurbituril compound of claim 1 , which is a CB[8] compound having phthalhydrazide units in a macrocycle wall thereof.