Thioether sulphamate steroids as steroid inhibitors and anti-cancer compounds
There is provided use of a compound of Formula XI: wherein R 3 is a sulphamate group and at least of R 1 or R 2 is a thioether group as disclosed by the present specification, capable of inhibiting steroid sulphatase.
1. A compound of Formula XI
wherein:
the rings may be independently substituted or unsubstituted, saturated or unsaturated;
R 1 is an optional group of the formula —S—R 1′ , wherein R 1′ is an alkyl group;
R 2 is an optional group of the formula —S—R 2′ —, wherein R 2′ is an alkyl group;
R 3 is a sulphamate group;
wherein at least one of R 1 and R 2 is present;
and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
2. A compound according to claim 1 wherein R 1′ and/or R 2′ are C 1 -C 10 alkyl groups.
3. A compound according to claim 1 wherein R 1′ and/or R 2′ are C 1 -C 6 alkyl groups.
4. A compound according to claim 1 wherein R 1′ and/or R 2′ are C 1 -C 3 alkyl groups.
5. A compound according to claim 1 wherein R 1′ and/or R 2′ are —CH 3 or —CH 2 CH 3 .
6. A compound according to claim 1 of the formula
7. A compound according to claim 1 of the formula
8. A pharmaceutical composition comprising the compound according to claim 1 optionally admixed with a pharmaceutically acceptable carrier, diluent, excipient or adjuvant.