Therapeutic compositions and methods of treating glycolipid storage related disorders
A method for treating a glycolipid storage-related disorder, comprising administering a therapeutically effective amount of an inhibitor of glycolipid synthesis in combination with an agent capable of increasing the rate of glycolipid degradation or in combination with bone marrow transplantation. Inhibitors of glycolipid synthesis include N-butyldeoxynojirimycin (NB-DNJ), N-butyldeoxygalactonojirimycin (NB-DGJ) or N-nonyldeoxynojirimycin (NN-DNJ). Glycolipid storage-related disorders include Gaucher disease, Sandhoff's disease, Fabry's disease, Tay-Sach's disease, Niemann-Pick C storage disease, GM1 gangliosidosis, genetic disorders in which neuronal glycolipid accumulation contributes to disease pathology.
1. A method for reducing accumulation of glucosylceramide-containing glycolipids in a patient afflicted with a glycolipid storage-related disorder, comprising administering to said patient afflicted with a glycolipid storage-related disorder an inhibitor of glycolipid synthesis in combination with an agent capable of increasing the rate of glycolipid degradation, wherein said inhibitor of glycolipid synthesis is N-butyldeoxynojirimycin (NB-DNJ) and is administered in an amount effective to reduce accumulation of glucosylceramide-containing glycolipids in said patient, and the agent capable of increasing the rate of glycolipid degradation is glucocerebrosidase.
2. The method of claim 1 , wherein the glycolipid storage-related disorder is selected from the group consisting of Gaucher disease, Sandhoff's disease, Fabry's disease, Tay-Sach's disease, Niemann-Pick disease, GM1 gangliosidosis, Alzheimer's disease, stroke, and epilepsy.
3. The method of claim 1 , wherein the inhibitor of glycolipid synthesis and the agent capable of increasing the rate of glycolipid degradation are given to said patient afflicted with a glycolipid storage-related disorder simultaneously, sequentially, or separately.
4. A method for augmenting glucocerebrosidase activity in a patient afflicted with a glycolipid storage-related disorder, comprising administering to said patient afflicted with a glycolipid storage-related disorder an inhibitor of glycolipid synthesis in combination with an agent capable of increasing the rate of glycolipid degradation, wherein the agent capable of increasing the rate of glycolipid degradation is glucocerebrosidase, and wherein said inhibitor of glycolipid synthesis is N-butyldeoxynojirimycin (NB-DNJ) and is administered in an amount effective to augment glucocerebrosidase activity in said patient.
5. A method for increasing the rate of glycolipid degradation in a patient afflicted with a glycolipid storage-related disorder, comprising administering to said patient afflicted with a glycolipid storage-related disorder an inhibitor of glycolipid synthesis in combination with an agent capable of increasing the rate of glycolipid degradation, wherein the agent capable of increasing the rate of glycolipid degradation is glucocerebrosidase and wherein the inhibitor of glycolipid synthesis is N-butyldeoxynojirimycin (NB-DNJ) and is administered in an amount effective to increase the rate of glycolipid degradation in said patient.
6. A method for improving survival of a patient afflicted with a glycolipid storage-related disorder, comprising administering to said patient afflicted with a glycolipid storage-related disorder an inhibitor of glycolipid synthesis in combination with an agent capable of increasing the rate of glycolipid degradation, wherein said inhibitor of glycolipid synthesis is N-butyldeoxynojirimycin (NB-DNJ) and is administered in an amount effective to improve survival of said patient, and the agent capable of increasing the rate of glycolipid degradation is glucocerebrosidase.