A method of forming particles comprises accelerating a stream comprising a liquid; and vibrating the stream, to form particles. The particle may have a diameter that is smaller than the diameter of the nozzle used to form the stream, allowing for the formation of micro- and nano-sized particle.
1. A method of forming particles, comprising:
accelerating a first stream comprising a first liquid;
vibrating the first stream, to form particles; and
solidifying the particles;
wherein the accelerating comprises contacting the first stream with a second stream.
2. The method of claim 1 , wherein the particles comprise a pharmaceutical composition.
3. The method of claim 1 , wherein the second stream comprises a second liquid.
4. The method of claim 3 , wherein the second stream surrounds the first stream.
5. The method of claim 1 , wherein
the second stream comprises a second liquid and surrounds the first stream, and
the accelerating further comprises accelerating the second stream.
6. The method of claim 5 , wherein the particles comprise a core and a shell.
7. The method of claim 6 , wherein the core comprises a pharmaceutical composition.
8. The method of claim 6 , wherein the particles comprise a plurality of shells.
9. The method of claim 1 , further comprising forming the first stream by passing the first liquid through a nozzle.
10. The method of claim 9 , wherein the nozzle has a diameter greater than ½ an average diameter of the particles.
11. The method of claim 10 , wherein the nozzle has a diameter at least the average diameter of the particles.
12. The method of claim 1 , wherein the particles have an average diameter of at most 100 μm.
13. The method of claim 1 , wherein the particles have an average diameter of at most 50 μm.
14. The method of claim 13 , wherein the particles have an average diameter of 10 nm to 50 μm.
15. The method of claim 13 , wherein the particles have an average diameter of 1 μm to 50 μm.
16. The method of claim 1 , wherein the particles have an average diameter of 50 to 100 μm, and 90% of the particles have a diameter that is within 2% of an average diameter of the particles.
17. The method of claim 1 , wherein the particles have an average diameter of 1 to 50 μm, and 90% of the particles have a diameter that is within 1 μm of an average diameter of the particles.
18. The method of claim 1 , wherein
the accelerating is a step for accelerating the first stream, and
the vibrating is a step for vibrating the first stream.
19. Particles, prepared by the method of claim 16 .
20. Particles, prepared by the method of claim 17 .
21. A method of forming particles, comprising:
accelerating a first stream comprising a first liquid; and
vibrating the first stream, to form particles;
wherein the accelerating comprises contacting the first stream with a second stream, and the second stream comprises a second liquid.
22. The method of claim 21 , wherein the second stream surrounds the first stream.
23. The method of claim 21 , wherein the particles comprise a core and a shell.
24. The method of claim 23 , wherein the core comprises a liquid.
25. The method of claim 24 , wherein the particles comprise a plurality of shells.
26. The method of claim 23 , wherein the particles comprise a plurality of shells.
27. The method of claim 21 , further comprising forming the first stream by passing the first liquid through a nozzle.
28. The method of claim 6 , wherein the core comprises a liquid.
29. The method of claim 28 , wherein the particles comprise a plurality of shells.
30. A method of forming particles, comprising:
accelerating a first stream comprising a first liquid;
vibrating the first stream, to form particles; and
solidifying the particles;
wherein the particles comprise a pharmaceutical composition.