Nucleic acids encoding B7-Like molecules and uses thereof
The present invention provides B7-Like (B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing B7-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with B7-L polypeptides.
1. An isolated nucleic acid molecule comprising the nucleotide sequence as set forth in SEQ ID NO: 1.
2. A vector comprising the nucleic acid molecule of claim 1 .
3. An isolated host cell comprising the vector of claim 2 .
4. The host cell of claim 3 that is a eukaryotic cell.
5. The host cell of claim 3 that is a prokaryotic cell.
6. A process of producing a B7-L polypeptide comprising culturing the host cell of claim 3 under suitable conditions to express the polypeptide, and optionally isolating the polypeptide from the culture.
7. The process of claim 6 , wherein the nucleic acid molecule comprises promoter DNA other than the promoter DNA for the native B7-L polypeptide operatively linked to the DNA encoding the B7-L polypeptide.
8. A composition comprising a nucleic acid molecule of claim 1 and a pharmaceutically acceptable formulation agent.
9. The composition of claim 8 , wherein said nucleic acid molecule is contained in a viral vector.
10. A viral vector comprising a nucleic acid molecule of any of claim 1 .
11. A nucleic acid molecule of claim 1 , attached to a solid support.
12. An array of nucleic acid molecules comprising at least one nucleic acid molecule of claim 1 .