EP
A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R 2 and R 5 is: (i) H or an optionally substituted C 1-4 alkyl group; or (ii)an optionally substituted C 5-7 aryl; and the other of R 2 and R 5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 R N is H or optionally substituted C 1-4 alkyl R 3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C 1-7 alkyl, C 5-20 aryl, or NR N3 R N4 , where R N3 and R N4 are independently selected from optionally substituted C 1-4 alkyl; or (iv) tetrazol-5-yl.
1. A compound of formula (I):
or a salt, solvate and chemically protected form thereof, wherein:
either R 2 is H or an optionally substituted C 1-4 alkyl group and R 5 is an optionally substituted C 5-7 aryl; or
R 5 is H or an optionally substituted C 1-4 alkyl group and R 2 is an optionally substituted C 5-7 aryl;
m and n can be 0 or 1, and m+n=1 or 2
R N is H or optionally substituted C 1-4 alkyl
R 3 is either:
a group of formula (II): or
a group of formula (III):
wherein R is optionally substituted C 1-7 alkyl, C 5-20 aryl, or NR N3 R N4 , where R N3 and R N4 are independently selected from optionally substituted C 1-4 alkyl.
2. A compound according to claim 1 , wherein R 5 is the optionally substituted C 5-7 aryl group and R 2 is H or the optionally substituted C 1-4 alkyl group.
3. A compound according to claim 2 , wherein R 2 is selected from H or an optionally substituted C 1-3 alkyl group.
4. A compound according to claim 3 , wherein R 2 is a methyl group.
5. A compound according to claim 2 , wherein R 5 is a C 6 aryl group.
6. A compound according to claim 5 , wherein R 5 is phenyl.
7. A compound according to claim 1 wherein the C 5-7 aryl group is substituted by substituents selected from C 1-7 alkoxy groups.
8. A compound according to claim 1 , wherein R is selected from an optionally substituted C 5-20 aryl group, and an optionally substituted C 5-20 aryl-C 1-7 alkyl group.
9. A compound according to claim 1 , wherein R is a C 1-7 alkyl group.
10. A compound according to claim 1 , wherein n+m=1.
11. A compound according to claim 10 , wherein n is 0 and m is 1.
12. A compound according to claim 1 , wherein R N is H or methyl.
13. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier or diluent.
14. A method of treating a headache disorder comprising administering to a patient in need of treatment an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.
15. A method according to claim 14 , wherein the headache disorder is a migraine.