IP Library › Granted Patent US 7,425,634
Granted Patent B2
US 7,425,634 · App. 11/520,838 · Granted Sep 16, 2008

Benzimidazole compound

Assignee: Eisai R&D Management Co., Ltd.
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Quick Facts
Patent No.
US 7,425,634
App. No.
11/520,838
Granted
Sep 16, 2008
Kind
B2
Abstract

An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R 1 and R 3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R 2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R 4 , R 5 , R 6 and R 7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W 1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

Claims (2)

1. 2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole or a salt thereof.

2. A sodium salt of 2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 14, 2008
From: EISAI CO., LTD.
To: EISAI R&D MANAGEMENT CO., LTD.
Reel/Frame 020511/0973 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 14, 2006
From: MIYAZAWA, SHUHEI; SHINODA, MASANOBU; KAWAHARA, TETSUYA; WATANABE, NOBUHISA; HARADA, HITOSHI; IIDA, DAISUKE; TERAUCHI, HIROKI; NAGAKAWA, JUNICHI; FUJISAKI, HIDEAKI; KUBOTA, ATSUHIKO; UEDA, MASATO
To: EISAI CO., LTD.
Reel/Frame 018314/0520 →
Priority Claims (1)
JP 2005-117643 · Apr 15, 2005 · national
Continuity (3)
Continuation In Part 1140381500 · Apr 14, 2006
Provisional Application 6067584800 · Apr 29, 2005
Related Publication 20070010542A1 · Jan 11, 2007