Granted Patent B2

US 7,427,600 · App. 10/923,088 · Granted Sep 23, 2008

Assignee: Shire LLC

Abstract

Claims (8)

1. A method of treating inflammatory bowel disease comprising administering to a patient in need thereof an effective amount of a compound consisting of mesalamine covalently attached to a single amino acid selected from Valine, Alanine, Asparagine, Isoleucine, Proline, Lysine, Cysteine, Glutamine, Histidine, Methionine, Phenylalanine, Serine, Threonine, Tryptophan and Tyrosine or a pharmaceutically acceptable salt thereof.

2. A compound consisting of mesalamine covalently attached to a single amino acid wherein said single amino acid is selected from Valine, Alanine, Asparagine, Isoleucine, Proline, Lysine, Cysteine, Glutamine, Histidine, Methionine, Phenylalanine, Serine, Threonine, Tryptophan and Tyrosine or a pharmaceutically acceptable salt thereof.

3. The compound of claim 2 , wherein the amino acid is Valine.

4. A pharmaceutical composition comprising:

a compound consisting of mesalamine covalently attached to a single amino acid selected from Valine, Alanine, Asparagine, Isoleucine, Proline, Lysine, Cysteine, Glutamine, Histidine, Methionine, Phenylalanine, Serine, Threonine, Tryptophan and Tyrosine or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient.

5. The pharmaceutical composition of claim 4 , wherein said composition is an oral dosage form.

6. The pharmaceutical composition of claim 4 , wherein the compound is mesalamine covalently attached to Valine.

7. The method of claim 1 , wherein the compound is mesalamine covalently attached to Valine.

Assignments (3)

Continuity (492)