Potassium channel modulators
This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SK Ca and/or IK Ca channels.
1. A compound represented by the following Formula
any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable salt therof, or an N-oxide thereof, wherein
m is 1;
n is 0;
X represents fluoro or chloro;
Ar 1 represents a phenyl group substituted with fluoro;
R represents phenyl substituted with fluoro; and
R 1 and R 2 both represent alkyl.
2. The compound of claim 1 , which is
[Tris-(4-fluoro-phenyl)-methyl]-phosphonic acid dimethyl ester;
[(2-Fluoro-phenyl)-bis-(4-fluoro-phenyl)-methyl]-phosphonic acid dimethyl ester;
[(2-Chloro-phenyl)-(2-fluoro-phenyl)-(4-fluoro-phenyl)-methyl]-phosphonic acid dimethyl ester; or
[(4-Chloro-phenyl)-bis-(4-fluoro-phenyl)-methyl]-phosphonic acid dimethyl ester;
any of its enantiomers or any mixture of enantiomers, or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.
3. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 or claim 2 , or a pharmaceutically-acceptable addition salt thereof, together with at least one pharmaceutically-acceptable carrier or diluent.