Pharmaceutical composition for the treatment of cardiovascular and cerebrovascular diseases
The present invention discloses a pharmaceutical composition for the treatment of cardiovascular and cerebrovascular diseases which comprises Radix Salviae Miltiorrhizae extract 5.0%-70.0%, Radix Notoginseng extract 10.0%-85.0%, Radix Astragali extract 5.0%-70.0%, and Bomeol or oil of Lignum Dalbergiae Odoriferae 1.0%-15.0%. The composition is active against cerebral ischemia and myocardial ischemia. The effects are superior to total phenic acid of Radix Salviae Miltiorrhizae or total saponin of Radix Notoginseng respectively, or the combination thereof. The composition of the invention can provide various kinds of preparations by the addition of various accessories. Thus the invention provides a more effective and convenient composition of TCM effective sections and its preparations.
1. A Pharmaceutical composition comprising:
5.0%-70.0% by weight Radix Salviae Miltiorrhizae extract;
10.0%-85.0% by weight Radix Notoginseng extract;
5.0%-70.0% by weight Radix Astragali extract; and
1.0%-15.0% by weight Borneol or oil of Lignum Dalbergiae Odoriferae,
wherein said Radix Salviae Miltiorrhizae extract comprises 45% -70% by weight salvianolic acid B, 2% -10% by weight salvianolic acid E, 4% -20% by weight rosmarinic acid, 1%-10% by weight lithospermic acid, and more than 70% by weight salvinolic acids;
said Radix Notoginseng extract comprises 2% -10% by weight notoginsenoside R1, 2% -6% by weight ginsenoside Re, 15% -40% by weight ginsenoside Rg1, 15%-40% by weight ginsenoside Rb1, 5% -12% by weight ginsenoside Rd, and more than 70% by weight radix notoginseng saponins; and
said Radix Astragali extract comprises 5% -15% by weight astragaloside I and more than 70% by weight Radix Astragali saponins.
2. The composition of claim 1 , comprising
15.0%-50.0% by weight Radix Salviae Miltiorrhizae extract;
25.0%-65.0% by weight Radix Notoginseng extract;
15.0%-50.0% by weight Radix Astragali extract; and
2.0%-12.0% by weight Borneol or oil of Lignum Dalbergiae Odoriferae.
3. The composition of claim 2 , comprising
20.0%-30.0% by weight Radix Salviae Miltiorrhizae extract;
30.0%-55.0% by weight Radix Notoginseng extract;
20.0%-30.0% by weight Radix Astragali extract; and
4.0%-10.0% by weight Borneol or oil of Lignum Dalbergiae Odoriferae.
4. The composition of claim 3 , comprising
23% by weight Radix Salviae Miltiorrhizae extract;
45.0% by weight Radix Notoginseng extract;
23% by weight Radix Astragali extract; and
9% by weight Borneol or oil of Lignum Dalbergiae Odoriferae.
5. The composition of claims 1 , wherein said Radix Salviae Miltiorrhizae extract comprises more than 80% by weight salvinolic acids; said Radix Notoginseng extract comprises more than 80% by weight radix notoginseng saponins; and said radix astragali extract comprises more than 80% by weight radix astragali saponins.
6. The composition of claims 1 , wherein the composition is in the dosage form of an injection, tablets, sustained-release tablets, drop pills, granules, injection powder, capsules, or microgranules.
7. The composition of claim 6 , wherein the composition is injection or injection powder.
8. A method for treating cardiovascular and cerebrovascular diseases in a subject, comprising administrating the composition of claim 1 to said subject in need of such treatment.
9. A method for treating cardiovascular and cerebrovascular diseases in a subject, comprising administrating the composition of claim 2 to said subject in need of such treatment.
10. A method for treating cardiovascular and cerebrovascular diseases in a subject, comprising administrating the composition of claim 3 to said subject in need of such treatment.
11. A method for treating cardiovascular and cerebrovascular diseases in a subject, comprising administrating the composition of claim 4 to said subject in need of such treatment.
12. A method for treating cardiovascular and cerebrovascular diseases in a subject, comprising administrating the composition of claim 5 to said subject in need of such treatment.
13. A method for treating cardiovascular and cerebrovascular diseases in a subject, comprising administrating the composition of claim 6 to said subject in need of such treatment.
14. A method for treating cardiovascular and cerebrovascular diseases in a subject, comprising administrating the composition of claim 7 to said subject in need of such treatment.