Irciniastatins a and b
View Patent ↗The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 0.001 to <0.0001 μg/ml) murine and human cancer cell growth inhibitors, denominated herein as irciniastatin A and irciniastatin B. Both were isolated (10-3 to 10-4% yields) by cancer cell line bioassay-guided techniques and named irciniastatins A (1) and B (2). Structural elucidation by a combination of spectral analyses, primarily high resolution mass and 2D-NMR (principally APT, HMQC, HMBC and ROESY) revealed unusual structures 1 and 2.
1. An essentially pure compound having a structure as follows:
wherein R═OH and R 1 ═H.
2. An essentially pure compound having a structure as follows:
wherein R═R 1 ═O.
3. A pharmaceutical composition comprising the compound of claim 1 .
4. A pharmaceutical composition comprising the compound of claim 2 .
5. A method for treating cells or tissue afflicted with neoplastic disease, comprising administering an effective amount of the composition of claim 3 .
6. A method for treating cells or tissue afflicted with neoplastic disease, comprising administering an effective amount of the composition of claim 4 .
7. A method for treating humans and animals having cancer, comprising administering a pharmaceutically effective amount of the composition of claim 3 .
8. A method for treating humans and animals having cancer, comprising administering a pharmaceutically effective amount of the composition of claim 4 .