IP Library › Granted Patent US 7,442,526
Granted Patent B2
US 7,442,526 · App. 11/402,187 · Granted Oct 28, 2008

Method for preparing a physiologically active IL-18 polypeptide

Assignee: SmithKline Beecham Corporation
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Quick Facts
Patent No.
US 7,442,526
App. No.
11/402,187
Granted
Oct 28, 2008
Kind
B2
Abstract

The present invention provides a method for producing physiologically active human Interleukin-18 (“IL-18”).

Claims (3)

1. A method for producing an active human IL-18 polypeptide from a human precursor IL-18 polypeptide, comprising:

(i) co-expressing bicistronically caspase 4, having the amino acid sequence of SEQ ID NO:4, with the human precursor IL-18 polypeptide; and

(ii) purifying the active IL-18 polypeptide.

Assignments (1)
CHANGE OF NAME Recorded Mar 10, 2010
From: SMITHKLINE BEECHAM CORPORATION
To: GLAXOSMITHKLINE LLC
Reel/Frame 024055/0203 →
Continuity (5)
Division 1031149100
Provisional Application 6021183200 · Jun 15, 2000
Provisional Application 6022412800 · Aug 10, 2000
Provisional Application 6026492300 · Jan 30, 2001
Related Publication 20060177422A1 · Aug 10, 2006