IP Library › Granted Patent US 7,446,120
Granted Patent B2
US 7,446,120 · App. 11/762,015 · Granted Nov 4, 2008

Peptidomimetic modulators of cell adhesion

Assignee: Adherex Technologies, Inc.
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Quick Facts
Patent No.
US 7,446,120
App. No.
11/762,015
Granted
Nov 4, 2008
Kind
B2
Abstract

Peptidomimetics of cyclic peptides, and compositions comprising such peptidomimetics are provided. The peptidomimetics have a three-dimensional structure that is substantially similar to a three-dimensional structure of a cyclic peptide that comprises a cadherin cell adhesion recognition sequence HAV. Methods for using such peptidomimetics for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.

Claims (5)

1. A method for modulating cellular adhesion, comprising contacting a cell with a cell adhesion modulating agent having the following structure:

2. A method according to claim 1 , wherein the method for modulating cellular adhesion is a method for modulating N-cadherin mediated cellular adhesion.

3. The method according to claim 1 , wherein the cell adhesion modulating agent is present within a composition comprising a physiologically acceptable carrier.

4. A method according to claim 1 , wherein the modulating agent is linked to a drug.

5. A method according to claim 1 , wherein the modulating agent is linked to a targeting agent.

Continuity (4)
Continuation 1041270100 · Apr 10, 2003
Continuation 0976914500 · Jan 24, 2001
Continuation In Part 0949107800 · Jan 24, 2000
Related Publication 20080081831A1 · Apr 3, 2008