Hairpin polyamide
It is intended to provide a pyrrole-imidazole polyamide type functional molecule having enhanced abilities of alkylating DNA and recognizing a sequence, compared with the existing functional molecules of this type, for a specific base sequence occurring on DNA. A hairpin polyamide having an alkylation site via a vinyl linker at the end of a pyrrole-imidazole polyamide. Drugs for inhibiting the expression of a specific gene and anticancer agents containing the above hairpin polyamide.
1. A hairpin polyamide having an alkylation reaction site via a vinyl linker on the terminal of a pyrrole-imidazole polyamide, wherein the hairpin polyamide is a compound represented by Formula [2]:
in which R 2 is a hydrogen, an alkyl group or an acetamide group, and k, p, q, m and n represents a natural number from 1 to 10 respectively or Formula [3]:
in which R 2 is a hydrogen, an alkyl group or an acetamide group, and k, p, q, m and n represents a natural number from 1 to 10 respectively.
2. The hairpin polyamide according to claim 1 wherein the compound represented by Formula [2] is a compound represented by the following structural formula:
3. The hairpin polyamide according to claim 1 wherein the compound represented by Formula [2] is a compound represented by the following structural formula:
4. The hairpin polyamide according to claim 1 wherein the compound represented by Formula [2] is a compound represented by the following structural formula:
5. The hairpin polyamide according to claim 1 wherein the compound represented by Formula [2] is a compound represented by the following structural formula:
6. The hairpin polyamide according to claim 1 wherein the compound represented by Formula [3] is a compound represented by the following structural formula:
7. An agent for inhibiting the expression of a specific gene which comprises a hairpin polyamide according to any of claims 1 , 2 - 5 and 6 .
8. An agent according to claim 7 wherein said specific gene is an abnormal gene.