Antibody that specifically binds to Chemerin receptor ligand precursor
The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
1. An isolated antibody or an antigen binding portion thereof that selectively binds to the amino acid sequence of SEQ ID NO: 89.
2. An isolated antibody or an antigen binding portion thereof that selectively binds to a polypeptide consisting of the sequence of SEQ ID NO: 89.
3. The antibody according to the claim 1 , wherein said antibody is a monoclonal antibody.
4. The antibody according to claim 3 , wherein said antibody is a single chain antibody.
5. The isolated antibody or antigen binding portion thereof of claim 1 , wherein said isolated antibody is a human antibody.
6. The isolated antibody or antigen binding portion thereof of claim 1 , wherein said isolated antibody is a humanized antibody.
7. The isolated antibody or antigen binding portion thereof of claim 1 , wherein the antibody is conjugated to a detectable label, an enzyme, a fluorescent label, a luminescent label, a bioluminscent label, or a therapeutic agent.