Compounds and methods for modulating functions of nonclassical cadherins
Modulating agents and methods for enhancing or inhibiting nonclassical cadherin-mediated functions, such as atypical or desmosomal cadherin-mediated functions, are provided. The modulating agents comprise at least a tryptophan-containing cell adhesion recognition sequence of an atypical and/or desmosomal cadherin, a conservative analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, pharmaceutically active substance and/or support material.
1. A cell adhesion modulating agent ranging in size from 6 to 15 amino acid residues that
(a) inhibits desmosomal cadherin-mediated cell adhesion; and
(b) consists essentially of the amino acid sequence Arg-Trp-Ala-Pro-Ile-Pro (SEQ ID NO: 2).
2. The cell adhesion modulating agent of claim 1 wherein the sequence consisting essentially of the amino acid sequence Arg-Trp-Ala-Pro-Ile-Pro (SEQ ID NO: 2) is C-terminal carboxylate esterified or amidated.
3. The cell adhesion modulating agent of claim 1 wherein the sequence consisting essentially of the amino acid sequence Arg-Trp-Ala-Pro-Ile-Pro (SEQ ID NO: 2) is N-acetylated.
4. The cell adhesion modulating agent of claim 1 linked to a solid support.
5. A composition comprising a cell adhesion modulating agent of claim 1 in combination with a physiologically acceptable carrier.