Patent
The present invention relates to antigens, more particularly antigens of Streptococcus pyogenes (also called group A Streptococcus (GAS)) bacterial pathogen which are useful as vaccine component for prophylaxis, therapy and/or diagnostic.
1. An isolated polypeptide comprising an amino acid sequence at least 95% identical to the full-length amino acid sequence set forth in SEQ ID NO:2, wherein the isolated polypeptide is capable of eliciting an immune response to Streptococcus pyogenes , and wherein the isolated polypeptide is capable of eliciting an antibody that specifically binds to a BVH-P7 polypeptide that consists of the amino acid sequence set forth in SEQ ID NO:2.
2. The isolated polypeptide of claim 1 comprising the amino acid sequence set forth in SEQ ID NO:2.
3. An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2 from which the N-terminal methionine residue is deleted.
4. An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2 which lacks the signal peptide consisting of the amino acid sequence at positions 1-21 of SEQ ID NO:2.
5. A pharmaceutical composition comprising the isolated polypeptide of any one of claims 1 - 4 and a pharmaceutically acceptable carrier, diluent or adjuvant.
6. A vaccine composition comprising the isolated polypeptide of any one of claims 1 - 4 and a pharmaceutically acceptable carrier, diluent or adjuvant.