Composition for inducing immune response comprising inverted microsomes
A vaccine composition is provided which comprises inverted microsomes or fragments thereof from an animal cell in association with an externally disposed peptide antigen and a protein of the MHC.
1. A composition for including an immune response comprising isolated inverted microsomes from an animal cell, or membrane fragments thereof, in association with a heterologous peptide antigen and a protein of the Major Histocompatibility Complex (MHC), wherein said peptide antigen and said protein of the MHC are externally disposed.
2. A composition as claimed in claim 1 , in which the microsome is from the endoplasmic reticulum of the cell.
3. A composition as claimed in claim 1 , in which the protein of the MHC is from a heterologous source with respect to the cell from which the microsomes are obtained.
4. A composition as claimed in claim 1 , in which the composition additionally comprises one or more cytokines.
5. A composition as claimed in claim 4 , in which the cytokine is IL-2.
6. A composition as claimed in claim 1 , in which the antigen is from a viral, bacterial, yeast, fungal, or protozoan origin.
7. A kit of parts comprising a composition as claimed in claim 1 and one or more cytokines and/or adjuvants in sealed containers.
8. A kit of parts as claimed in claim 7 , in which the cytokine is IL-2 or IFNγ.
9. A kit of parts comprising a composition as claimed in claim 1 and one or more cytokines and/or adjuvants for separate, subsequent or simultaneous administration to a subject.
10. A kit of parts as claimed in claim 9 , in which the cytokine is IL-2 or IFNγ.
11. A composition comprising isolated inverted microsomes from an animal cell, or membrane fragments thereof, in association with a heterologous peptide antigen and a protein of the Major Histocompatibility Complex (MHC), wherein said peptide antigen and said protein of the MHC are externally disposed.
12. A composition as claimed in claim 11 , in which the microsome is from the endoplasmic reticulum of the cell.
13. A composition as claimed in claim 11 , in which the protein of the MHC is from a heterologous source with respect to the cell from which the microsomes are obtained.
14. A composition as claimed in claim 11 , in which the composition additionally comprises one or more cytokines.
15. A composition as claimed in claim 14 , in which the cytokine is IL-2.
16. A composition as claimed in claim 11 , in which the antigen is from a viral, bacterial, yeast, fungal, or protozoan origin.
17. A kit of parts comprising a composition as claimed in claim 11 and one or more cytokines and/or adjuvants in sealed containers.
18. A kit of parts as claimed in claim 17 , in which the cytokine is IL-2 or IFNγ.
19. A kit of parts comprising a composition as claimed in claim 11 and one or more cytokines and/or adjuvants for separate, subsequent or simultaneous administration to a subject.
20. A kit of parts as claimed in claim 19 , in which the cytokine is IL-2or IFNγ.