IP Library › Granted Patent US 7,514,549
Granted Patent B2
US 7,514,549 · App. 11/404,766 · Granted Apr 7, 2009

Tumor inhibition by modulating sprouty expression or activity

Assignee: Michigan State University
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Quick Facts
Patent No.
US 7,514,549
App. No.
11/404,766
Granted
Apr 7, 2009
Kind
B2
Abstract

Methods are provided for identifying compounds that decrease the expression or activity of an overexpressed Sprouty protein in certain cancers. Such compounds can be useful for treating cancers in which a Sprouty protein is overexpressed. Also provided are therapeutic formulations and pharmaceutical formulations for treating cancers characterized by overexpression of a Sprouty protein.

Claims (10)

1. A composition comprising a Sprouty2 siRNA that decreases Sprouty2 expression or activity, wherein the Sprouty2 siRNA comprises a sequence expressed from a vector sequence comprising SEQ ID NO: 1, wherein the sequence is at least 16 nucleotides in length.

2. The composition of claim 1 , wherein the Sprouty2 siRNA comprises an RNA sequence that corresponds to 30 nucleotides of the DNA sequence of SEQ ID NO: 1.

3. The composition of claim 1 , wherein the Sprouty2 siRNA comprises an RNA sequence that corresponds to 25 nucleotides of the DNA sequence of SEQ ID NO: 1.

4. The composition of claim 1 , wherein the Sprouty2 siRNA comprises an RNA sequence that corresponds to 20 nucleotides of the DNA sequence of SEQ ID NO: 1.

5. The composition of claim 1 , wherein the Sprouty2 siRNA comprises an RNA sequence that corresponds to 16 nucleotides of the DNA sequence of SEQ ID NO: 1.

6. The composition of claim 1 , wherein the Sprouty2 siRNA consists of an RNA sequence that corresponds to 30 nucleotides of the DNA sequence of SEQ ID NO: 1.

7. The composition of claim 1 , wherein the Sprouty2 siRNA consists of an RNA sequence that corresponds to 25 nucleotides of the DNA sequence of SEQ ID NO: 1.

8. The composition of claim 1 , wherein the Sprouty2 siRNA consists of an RNA sequence that corresponds to 20 nucleotides of the DNA sequence of SEQ ID NO: 1.

9. The composition of claim 1 , wherein the Sprouty2 siRNA consists of an RNA sequence that corresponds to 16 nucleotides of the DNA sequence of SEQ ID NO: 1.

10. A pharmaceutical composition comprising (i) the composition of any one of claims 1 - 9 , and (ii) a pharmaceutical carrier.

Assignments (6)
CONFIRMATORY LICENSE Recorded Feb 24, 2015
From: MICHIGAN STATE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 035072/0451 →
CONFIRMATORY LICENSE Recorded Nov 8, 2013
From: MICHIGAN STATE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031600/0631 →
CONFIRMATORY LICENSE Recorded Sep 12, 2011
From: MICHIGAN STATE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 026908/0682 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 22, 2008
From: PIRO, LITO
To: MICHIGAN STATE UNIVERSITY
Reel/Frame 021320/0519 →
CONFIRMATORY LICENSE Recorded Jul 21, 2008
From: MICHIGAN STATE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 021320/0580 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2006
From: MCCORMICK, J. JUSTIN
To: MICHIGAN STATE UNIVERSITY
Reel/Frame 018144/0163 →
Continuity (2)
Provisional Application 6067178300 · Apr 16, 2005
Related Publication 20070066522A1 · Mar 22, 2007