Anti-TNF antibodies, compositions, methods and uses
The present invention relates to at least one novel anti-TNF antibodies, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
1. An isolated nucleic acid encoding at least one isolated mammalian anti-TNF antibody comprising both the heavy chain and light chain variable regions comprising SEQ ID NO:7 and 8.
2. An isolated nucleic acid vector comprising an isolated nucleic acid according to claim 1 .
3. A prokaryotic or eukaryotic host cell comprising an isolated nucleic acid according to claim 2 .
4. A prokaryotic or eukaryotic host cell comprising a nucleic acid vector comprising an isolated nucleic acid encoding at least one isolated mammalian anti-TNF antibody comprising both the heavy chain and light chain variable regions comprising SEQ ID NO:7 and 8, wherein said host cell is at least one selected from COS-1, COS-7, HEK293, BHK21, CHO, BSC-1, Hep G2, 653, SP2/0, 293, HeLa, myeloma, or lymphoma cells, or any derivative, immortalized or transformed cell thereof.
5. A method for producing at least one anti-TNF antibody, comprising translating a nucleic acid according to claim 1 under conditions in vitro, in vivo or in situ, such that the TNF antibody is expressed in detectable or recoverable amounts.