C-linked glucuronide of
Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans.
1. A compound of Formula I:
wherein X is CH 2 ; Y is C 1 -C 6 alkylene; and R is selected from the group consisting of hydrogen, C 1 -C 6 alkyl,
wherein R 1 is selected from the group consisting of H, OH, COOH, C 1 -C 6 alkyl, alkenyl, alkynyl, and C 1 -C 6 -hydroxyalkyl; R 2 is OH;
or a salt thereof.
2. The compound of claim 1 , wherein R is hydrogen.
3. The compound of claim 1 , wherein R is C 1 -C 6 alkyl.
4. The compound of claim 1 , wherein R is
5. The compound of claim 4 , wherein R 1 is H.
6. The compound of claim 4 , wherein R 1 is COOH.
7. The compound of claim 4 , wherein R 1 is CH 2 OH.
8. The compound of claim 4 , wherein R 1 is OH.
9. The compound of claim 1 , wherein R is
10. A pharmaceutical composition for inhibiting formation of breast cancer and treating breast cancer in mammals, the composition comprising an effective breast cancer cell growth-inhibiting amount of a compound according to claim 1 , or a pharmaceutically-suitable salt thereof, optionally in combination with a pharmaceutically-suitable carrier.
11. A method of inhibiting formation of breast cancer and treating breast cancer in mammals, the method comprising administering a breast cancer cell growth-inhibiting amount of a compound according to claim 1 , or a pharmaceutically-suitable salt thereof, to a patient in need thereof.