Process for purification of 2-chloro-5-chloromethyl-1,3-thiazole
View Patent ↗The present invention provides a process for purifying 2-chloro-5-chloromethyl-1,3-thiazole represented by the formula (I): characterized in that a crude 2-chloro-5-chloromethyl-1,3-thiazole represented by the formula (I) is treated with a lower alcohol before the distillation, and then is distilled. The present purification process is a new one for purifying 2-chloro-5-chloromethyl-1,3-thiazole, suitable for industrial practice.
1. A process for purifying 2-chloro-5-chloromethyl-1,3-thiazole represented by the formula (I):
which consists essentially of:
treating a crude 2-chloro-5-chloromethyl-1,3-thiazole represented by the formula (I) with a lower alcohol, and then
distilling the treated 2-chloro-5-chloromethyl-1,3-thiazole.
2. The process for purifying 2-chloro-5-chloromethyl-1,3-thiazole according to claim 1 , wherein the crude 2-chloro-5-chloromethyl-1,3-thiazole is treated with the lower alcohol by adding the lower alcohol to the crude 2-chloro-5-chloromethyl-1,3-thiazole, followed by stirring.
3. The process for purifying 2-chloro-5-chloromethyl-1,3-thiazole according to claim 2 , wherein the lower alcohol is methanol.
4. The process for purifying 2-chloro-5-chloromethyl-1,3-thiazole according to claim 1 , wherein the crude 2-chloro-5-chloromethyl-1,3-thiazole is a reaction mixture obtained by reacting a 2-halogenoallyl isothiocyanate represented by the general formula (II):
wherein Hal represents a chlorine atom or a bromine atom, with a chlorinating agent in the presence of a solvent, or
wherein the crude 2-chloro-5-chloromethyl-1,3-thiazole is a residue obtained by distilling the solvent from the reaction mixture.
5. The process for purifying 2-chloro-5-chloromethyl-1,3-thiazole according to claim 4 , wherein the crude 2-chloro-5-chloromethyl-1,3-thiazole is a residue obtained by distilling the solvent from the reaction mixture.
6. The process for purifying 2-chloro-5-chloromethyl-1,3-thiazole according to claim 5 , wherein the lower alcohol is methanol.
7. The process for purifying 2-chloro-5-chloromethyl-1,3-thiazole according to claim 6 , wherein Hal is a chlorine atom.
8. The process for purifying 2-chloro-5-chloromethyl-1,3-thiazole according to claim 5 , wherein Hal is a chlorine atom.
9. The process for purifying 2-chloro-5-chloromethyl-1,3-thiazole according to claim 4 , wherein the lower alcohol is methanol.
10. The process for purifying 2-chloro-5-chloromethyl-1,3-thiazole according to claim 9 , wherein Hal is a chlorine atom.
11. The process for purifying 2-chloro-5-chloromethyl-1,3-thiazole according to claim 4 , wherein Hal is a chlorine atom.
12. The process for purifying 2-chloro-5-chloromethyl-1,3-thiazole according to claim 1 , wherein the lower alcohol is methanol.