Granted Patent
B2
US 7,547,726 · App. 11/228,707 · Granted Jun 16, 2009
AI-2 compounds and analogs based on
Assignee:
The Trustees of Princeton University
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Abstract
This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium . The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
Claims (2)
1. A composition comprising an isolated natural compound or a chemically synthesized compound having the chemical formula:
2. The composition of claim 1 wherein the compound is in admixture with a pharmaceutically acceptable carrier.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Nov 19, 2015
From: PRINCETON UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 037146/0407 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 13, 2005
From: MILLER, STEPHEN T.; XAVIER, KARINA B.; TAGA, MICHIKO E.; CAMPAGNA, SHAWN R.; SEMMELHACK, MARTIN F.; BASSLER, BONNIE L.; HUGHSON, FREDERICK M.
To: THE TRUSTEES OF PRINCETON UNIVERSITY
Reel/Frame 016889/0710 →
Continuity (3)
Provisional Application
6056165900
· Apr 12, 2004