N-oxides of N-phenyl-2-pyrimidine-amine derivatives
The invention relates to N-phenyl-2-pyrimidine-amine derivatives in which at least one nitrogen atom carries an oxygen atom to form the corresponding N-oxides, to processes for the preparation thereof, to pharmaceutical compositions comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.
1. A compound of formula I
wherein
R 1 is hydrogen or hydroxy,
R 2 is hydrogen, lower alkyl or hydroxy-lower alkyl,
A is a piperazinyl group of the formula A′
substituted by oxo on a ring carbon, and
R 3 is hydrogen, lower alkyl or acetyl,
in purified form or a pharmaceutically acceptable salt of such a compound.
2. A compound selected from the group consisting of 4-[(3-oxo-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide and 4-[(4-methyl-3-oxo-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide or a pharmaceutically acceptable salt thereof.
3. A compound which is 4-[(4-methyl-4-oxido-1-piperazinyl)-methyl]-N-{4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]-amino]-phenyl}-benzamide or a pharmaceutically acceptable salt thereof.
4. A compound which is 4-[(4-methyl-1,4-dioxido-1-piperazinyl)-methyl]-N-{4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]-amino]-phenyl}-benzamide, or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.