Inhibitors of Akt activity

Assignee: Merck & Co., Inc.

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Quick Facts

Patent No.: US 7,576,209
App. No.: 11/999,234
Granted: Aug 18, 2009
Kind: B2

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Abstract

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

Claims (3)

1. A compound which is:

8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-3(2H)-one;

or a pharmaceutically acceptable salt thereof.

Assignments (5)

MERGER Recorded Aug 8, 2022

From: MERCK SHARP & DOHME CORP.

To: MERCK SHARP & DOHME LLC

Reel/Frame 061102/0145 →

CHANGE OF NAME Recorded Aug 29, 2012

From: SCHERING CORPORATION

To: MERCK SHARP & DOHME CORP.