Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R 1 to R 6 as well as R 7a , R 7b , R 7c are defined herein and the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
1. Glucopyranosyl-substituted benzene derivatives of general formula I.2c
wherein
R 1 is selected from hydrogen, fluorine, chlorine, bromine, cyano, methyl, ethyl, isopropyl, ethynyl, hydroxy, methoxy, ethoxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy, and
R 2 is hydrogen, fluorine, hydroxy, methoxy, ethoxy or methyl, and
R 3 is selected from trimethylsilylethyl, ethynyl, 2-hydroxyprop-2-ylethynyl, 2-methoxyprop-2-ylethynyl, 3-hydroxy-1-propyn-1-yl, 3-methoxy-1-propyn-1-yl, cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy, tetrahydrofuran-3-yloxy, tetrahydropyran-4-yloxy, piperidin-4-yloxy, N-methylpiperidin-4-yloxy and N-acetylpiperidin-4-yloxy, and
R 4 , R 5 independently of one another is hydrogen or fluorine, and
R 6 is hydrogen, (C 1-6 -alkyl)carbonyl or (C 1-6 -alkyl)oxycarbonyl, and
R 7a , R 7b and R 7c are hydrogen,
while, unless otherwise stated, the above-mentioned alkyl groups may be straight-chain or branched,
the stereoisomers thereof, the mixtures thereof and the salts thereof.
2. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 1 is methyl or chlorine.
3. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 3 is ethynyl.
4. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 3 is trimethylsilylethyl.
5. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 3 is cyclobutyloxy.
6. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 3 is cyclopentyloxy.
7. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 3 is cyclohexyloxy.
8. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 3 is tetrahydrofuran-3-yloxy.
9. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 3 is tetrahydropyran-4-yloxy.
10. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 2 is hydrogen or methyl.
11. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 2 is hydrogen.
12. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 4 and R 5 are hydrogen.
13. Glucopyranosyl-substituted benzene derivatives according to claim 1 , wherein R 6 is hydrogen.
14. 1 -Chloro-2-(4-cyclopentyloxybenzyl)-4-(β-D-glucopyranos- 1-yl)-benzene.
15. 1 -Chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene.
16. 1 -Chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene.
17. 1 -Chloro-4-(β-D-glucopyranos-1-yl)-2-(4-cyclobutyloxy-benzyl)-benzene.
18. 1 -Chloro-4-(β-D-glucopyranos-1-yl)-2-(4-cyclohexyloxy-benzyl)-benzene.
19. 1 -Chloro-4-(β-D-glucopyranos-1-yl)-2-[4-(tetrahydropyran-4-yloxy)-benzyl]-benzene.
20. 1 -Chloro-4-(β-D-glucopyranos-1-yl)-2-[4-(1-acetyl-piperidin-4-yloxy)-benzyl]-benzene.
21. 1-(β-D-Glucopyranos-1-yl)-4-methyl-3-[4-(2-trimethylsilyl-ethyl)-benzyl]-benzene.
22. 1-Chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene.
23. 1-Fluoro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene.
24. 1-(β-D-Glucopyranos-1-yl)-3-(4-ethynyl-benzyl)-benzene.
25. 1-Methoxy-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene.