Inhibitors of the anandamide transporter
Disclosed are compounds that are anandamide transport inhibitors and their pharmacological use.
1. A compound having the structure
wherein Z is selected from a heterocyclic ring, a substituted heterocyclic ring, a heteroaromatic ring or a substituted heteroaromatic ring.
2. The compound of claim 1 having the structure of any of compounds 17 to 25:
3. A compound selected from the following structures and physiologically acceptable salts thereof:
4. A compound from claim 3 selected from the following structures and physiologically acceptable salts thereof:
5. A pharmaceutical composition prepared from a compound as disclosed in claim 1 .
6. A pharmaceutical composition prepared from a compound as disclosed in claim 3 and physiological acceptable salts thereof.
7. The pharmaceutical composition of claim 6 selected from the following structures and physiologically acceptable salts thereof: