Compounds for the treatment of tobacco dependence and withdrawal
The invention provides methods for treating or suppressing tobacco or nicotine usage or dependence involving administration of a therapeutically-effective amount of a cytosine-containing or cytidine-containing compound, creatine-containing compound, adenosine-containing, or adenosine-elevating compound to a mammal.
1. A method of treating or suppressing tobacco or nicotine dependence or usage, said method comprising administering to a mammal a therapeutically-effective amount of a compound selected from the group consisting of a cytidine-containing compound, a cytosine-containing compound, and a uridine-containing compound.
2. The method of claim 1 , wherein said cytidine-containing compound is cytidine and is administered.
3. The method of claim 1 , wherein said cytidine-containing compound further comprises choline.
4. The method of claim 1 , wherein said cytidine-containing compound is CDP-choline.
5. The method of claim 4 , wherein said CDP-choline is administered orally.
6. The method of claim 1 , wherein said cytidine-containing compound is CDP and is administered.
7. The method of claim 1 , wherein said administering is chronic.
8. The method of claim 1 , wherein said mammal is a human.
9. The method of claim 8 , wherein said human is a child or adolescent.
10. The method of claim 8 , wherein said human is an older adult.
11. The method of claim 1 , wherein said cytidine-containing compound is CMP, CDP, CTP, dCMP, dCDP, or dCTP and is administered.
12. The method of claim 1 , wherein said cytosine-containing compound is cytosine and is administered.
13. The method of claim 1 , wherein said uridine-containing compound is uridine, triacetyl uridine, UMP, UDP, or UTP and is administered.