System and method for determining fill volume in a container
A system and method for detecting a pathogen in a sample is provided, the system capable of measuring the volume of a sample in a container through the use of various measurement technologies, thereby ensuring that a user is aware of volumes not meeting specification and/or allowing correction of results to account for the out-of-specification sample.
1. A system for detecting a pathogen in a sample, comprising
a plurality of sample containers comprising a growth medium and adapted to receive a biological fluid sample;
an incubation and measurement module comprising a plurality of individual openings, each opening adapted to receive one of the plurality of sample containers;
a sample volume sensor, separate from or part of said incubation and measurement module, the sensor adapted to measure the sample volume of said sample containers; and
one or more interfaces adapted to perform one or more tasks selected from the group consisting of (a) notifying a user if said sample containers are not within predetermined sample volume specifications, (b) accepting instructions on subsequent handling of said sample containers that are not within predetermined sample volume specifications, and (c) prompting user to place said sample container into a test rack of said incubation and measurement module if sample volume is within sample volume specification.
2. The system of claim 1 wherein said sample volume sensor is part of said incubation and measurement module.
3. The system of claim 1 wherein said sample volume sensor is separate from said incubation and measurement module.
4. The system of claim 1 further comprising a computer for notifying the user if said sample containers are not within predetermined sample volume specifications and for prompting the user for a response.
5. The system of claim 1 further comprising a computer for applying an algorithm to augment detection sensitivity, if said sample volume is less than said sample volume specification.
6. The system of claim 5 , wherein said algorithm is a positivity sense boost algorithm.
7. The system of claim 1 further comprising a computer for applying an alternate background filter, if said sample volume is greater than said sample volume specification.
8. The system of claim 1 wherein said interfaces are at least one component selected from the group consisting of a keyboard and a barcode reader.
9. The system of claim 1 wherein said sample volume sensor comprises an ultrasonic reflectometry apparatus.
10. The system of claim 1 wherein said sample volume sensor comprises a laser displacement sensing apparatus.
11. The system of claim 1 wherein said sample volume sensor comprises a through beam optical sensor apparatus.
12. The system of claim 1 wherein said sample volume sensor comprises a laser scanning photodiode array.
13. The system of claim 1 wherein said sample volume sensor comprises a refractive index, internal reflection apparatus.
14. The system of claim 1 wherein said sample volume sensor comprises a weight variation detection apparatus.
15. The system of claim 1 wherein said sample volume sensor comprises a retro-reflective optical detection apparatus.
16. The system of claim 1 wherein said sample volume sensor comprises a machine vision apparatus.
17. The system of claim 1 wherein said sample volume sensor comprises a capacitive proximity detection apparatus.
18. The system of claim 1 wherein said sample volume sensor comprises a fluorescent, luminescent or phosphorescent detection apparatus.
19. The system of claim 1 wherein said sample volume sensor comprises an optical scattering apparatus.
20. The system of claim 1 wherein said sample volume sensor comprises a nuclear magnetic resonance apparatus.