Phenylacetic acid compounds
The present invention provides a process for the preparation 6-[3-(hetero)aryloxy-2-fluoro-benzyl]-2H-pyridazin-3-one compounds 1 where R2 is an optionally substituted aryl or an optionally substituted heteroaryl, R 6 is NO 2 , NH 2 , alkyl, halogen, or a function group readily derived therefrom and R 4c is hydrogen or alkyl. There also is provided a process for the preparation of phenylacetic acid compounds 2, wherein R 2 and R 6 are as defined previously and R 5a is hydrogen or alkyl, which are useful for the preparation of pyridazinone compounds.
1. A compound according to formula Va wherein:
R 2 is an aryl radical and said aryl radical is optionally substituted with zero to three substituents independently selected from the group consisting of C 1-6 alkyl, C 1-6 alkenyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 sulfonyl, C 1-6 haloalkoxy, C 1-6 haloalkylthio, hydroxyl, halogen, amino, C 1-6 alkylamino, C 1-6 dialkylamino, C 1-6 N,N-dialkylcarbamoyl, nitro and cyano;
R 4a is in each occurrence is independently hydrogen, C 1-6 alkyl or benzyl;
R 5 is H or CO 2 R 5a : and
R 5a is independently in each occurrence a straight or branched C 1-6 alkyl.