Water-stabilized antimicrobial organosilane products, compositions, and methods for using the same
The present invention relates to water-stable compositions and compounds formed by mixing an organosilane, optionally having a non-hydrolyzable organic group, but having one or more hydrolyzable groups, and an acidified stabilizing solution prepared from at least one acid, at least one glycol ether, and at least one cationic surfactant, preferably at least one quaternary ammonium salt (QAS), in water. The present invention also relates to methods of treating a substrate by mixing or contacting the substrate with the product, compound, or composition of this invention for a period of time sufficient for treatment of the substrate, methods of antimicrobially treating a food article, methods of antimicrobially coating a fluid container, methods of dyeing and treating a substrate, and methods of antimicrobially coating a latex medical article. The invention also pertains to a treated substrate having adhered thereto the product, compound, or composition of this invention.
1. A composition comprising an organosilane and an acidic stabilizing solution:
wherein the organosilane is 3-(trimethoxysilyl)propyl-dimethyloctadecyl ammonium chloride; and
the acid stabilizing solution comprises at least one acid comprising hydrochloric acid, at least one glycol ether comprising diethylene glycol butyl ether, and at least one cationic surfactant in water, wherein the cationic surfactant is a quaternary ammonium salt having the following structure:
wherein each of R 38 , R 39 , R 40 , and R 41 are independently selected from the group consisting of alkyl, aryl, and arylalkyl, or the nitrogen may be part of a ring system; and wherein X is an anion.
2. The composition according to claim 1 , wherein the acidic stabilizing solution comprises exactly one acid, exactly one glycol ether, and exactly one cationic surfactant in water.
3. The composition according to claim 1 , wherein at least one of R 38 , R 39 , R 40 , or R 41 is an alkyl.
4. The composition according to claim 1 , wherein the quaternary ammonium salt is an N-alkyl-N, N-Dimethyl-N-Benzyl ammonium chloride.
5. The composition according to claim 1 , wherein the pH of the acidic stabilizing solution is between about 2 and about 3.
6. The composition according to claim 5 , wherein the pH of the acidic stabilizing solution is about 2.5.
7. The composition according to claim 1 , wherein the organosilane comprises from about 0.1 wt % to about 50 wt % of the composition.
8. A method for producing an antimicrobial organosilane composition according to claim 1 , comprising:
a) mixing the at least one quaternary ammonium salt with the at least one glycol ether and water to produce a solution;
b) adding the at least one acid to the solution to acidify the solution; and
c) adding the solution to the organosilane.
9. The method according to claim 8 , wherein at least one quaternary ammonium salt is an N-alkyl-N,N-Dimethyl-N-Benzyl ammonium chloride.
10. The method according to claim 8 , comprising:
a) mixing exactly one quaternary ammonium salt with a glycol ether and water to produce a solution; and
b) adding exactly one acid to the solution to acidify the solution.
11. The method according to claim 8 wherein the pH of the solution after acidifying the solution is between about 2 and about 3.
12. The method according to claim 11 , wherein the pH of the solution after acidifying the solution is about 2.5.
13. The method according to claim 8 , wherein the organosilane comprises about 0.1 wt % to about 50 wt % of the antimicrobial organosilane composition.
14. The method according to claim 8 , wherein the at least one quaternary ammonium salt comprises about 0.1 wt % to about 5 wt % of the solution.
15. The method according to claim 8 , wherein the at least one glycol ether comprises about 5 wt % to about 20% of the solution.
16. A composition formed by mixing an organosilane and an acidic stabilizing solution:
wherein the organosilane is 3-(trimethoxysilyl)propyl-dimethyloctadecyl ammonium chloride; and
the acid stabilizing solution comprises at least one acid comprising hydrochloric acid, at least one glycol ether comprising diethylene glycol butyl ether, and at least one cationic surfactant in water, wherein the cationic surfactant is a quaternary ammonium salt having the following structure:
wherein each of R 38 , R 39 , R 40 , and R 41 are independently selected from the group consisting of alkyl, aryl, and arylalkyl, or the nitrogen may be part of a ring system; and wherein X is an anion.
17. The composition according to claim 16 , wherein at least one of R 38 , R 39 ,R 40 , or R 41 is an alkyl.
18. The composition according to claim 16 , wherein the quaternary ammonium salt is an N-alkyl-N,N-Dimethyl-N-Benzyl ammonium chloride.
19. The composition according to claim 16 , wherein the pH of the acidic stabilizing solution is about 2.5.