IP Library › Granted Patent US 7,645,857
Granted Patent B2
US 7,645,857 · App. 11/183,567 · Granted Jan 12, 2010

Methods of indentifying modulators of the FGF receptor

Assignee: Mount Sinai School of Medicine
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Quick Facts
Patent No.
US 7,645,857
App. No.
11/183,567
Granted
Jan 12, 2010
Kind
B2
Abstract

The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is also included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the fragments are also provided.

Claims (2)

1. An isolated peptide derived from FGFR1 consisting of 16 to 50 amino acids comprising the amino acid sequence of SEQ ID NO:5: Val Xaa Xaa Leu Xaa Xaa Xaa Ile Xaa Leu Xaa Arg Xaa Val Xaa Val.

2. An isolated peptide derived from FGFR1 consisting of 16 to 50 amino acids comprising the amino acid sequence of SEQ ID NO:3.

Assignments (1)
CONFIRMATORY LICENSE Recorded Jul 7, 2016
From: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 039276/0194 →
Continuity (3)
Continuation 0975741500 · Jan 9, 2001
Provisional Application 6017586700 · Jan 12, 2000
Related Publication 20060019296A1 · Jan 26, 2006